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Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
It is found that a functional polymorphism altering chromatin interaction between the transcription start site and long-range enhancers in the FK506 binding protein 5 gene increased the risk of developing stress-related psychiatric disorders in adulthood by allele-specific, childhood trauma–dependent DNA demethylation in functional glucocorticoid response elements of FKBP5.
Major depressive disorder
An overview of the current evidence of major depressive disorder, including its epidemiology, aetiology, pathophysiology, diagnosis and treatment, is provided.
The HPA axis in major depression: classical theories and new developments
Effects of perinatal mental disorders on the fetus and child
Identifying the women at risk of antenatal anxiety and depression: A systematic review
Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers.
- A. Danese, T. Moffitt, A. Caspi
- Medicine, PsychologyArchives of Pediatrics & Adolescent Medicine
- 7 December 2009
Children exposed to adverse psychosocial experiences have enduring emotional, immune, and metabolic abnormalities that contribute to explaining their elevated risk for age-related disease.
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Childhood maltreatment predicts adult inflammation in a life-course study
- A. Danese, C. Pariante, A. Caspi, A. Taylor, R. Poulton
- PsychologyProceedings of the National Academy of Sciences
- 23 January 2007
Childhood maltreatment is a previously undescribed, independent, and preventable risk factor for inflammation in adulthood, and may be an important developmental mediator linking adverse experiences in early life to poor adult health.
Elevated inflammation levels in depressed adults with a history of childhood maltreatment.
- A. Danese, T. Moffitt, C. Pariante, A. Ambler, R. Poulton, A. Caspi
- Psychology, MedicineArchives of General Psychiatry
- 1 April 2008
Information about experiences of childhood maltreatment may help to identify depressed individuals with elevated inflammation levels and, thus, at greater risk of cardiovascular disease.