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Gene Silencing

Known as: Silencing, Gene, Gene Inactivation, silencing gene 
Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA… Expand
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Despite their widespread roles as regulators of gene expression, important questions remain about target regulation by microRNAs… Expand
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Review
2009
Review
2009
Polycomb proteins form chromatin-modifying complexes that implement transcriptional silencing in higher eukaryotes. Hundreds of… Expand
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Review
2006
Review
2006
Chromatin alterations have been associated with all stages of tumour formation and progression. The best characterized are… Expand
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Highly Cited
2006
Highly Cited
2006
Plant microRNAs (miRNAs) affect only a small number of targets with high sequence complementarity, while animal miRNAs usually… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation… Expand
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Review
2004
Review
2004
Double-stranded RNA (dsRNA) is an important regulator of gene expression in many eukaryotes. It triggers different types of gene… Expand
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Highly Cited
2003
Highly Cited
2003
Genome-wide genetic approaches have proven useful for examining pathways of biological significance in model organisms such as… Expand
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Review
2002
Review
2002
Among the 3 billion base pairs of the human genome, there are ∼30,000–40,000 protein-coding genes, but the function of at least… Expand
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Highly Cited
2001
Highly Cited
2001
Post-transcriptional silencing of plant genes using anti-sense or co-suppression constructs usually results in only a modest… Expand
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Highly Cited
1999
Highly Cited
1999
Posttranscriptional gene silencing (PTGS) is a nucleotide sequence-specific defense mechanism that can target both cellular and… Expand
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