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GYKI 14766

Known as: GYKI-14766 
National Institutes of Health

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2005
2005
Molecular basis for the inhibition of human a-thrombin by the macrocyclic peptide cyclotheonamide A ( serine protease / a-keto amide / transition-state analogue / x-ray crystallography / total…
The macrocyclic peptide cyclotheonamide A (CtA), isolated from the marine sponge Theonella sp., represents an unusual class of… 
1996
1996
Antithrombotic effect of GYKI-14766 in a canine model of arterial and venous rethrombosis: a comparison with heparin.
We compared the antithrombotic effects of the thrombin inhibitor, D-methyl-phenylalanyl-prolyl-arginal (GYKI-14766) with those of… 
1994
1994
Biochemical effect and kinetics of thrombin inhibition by GYKI-14766.
The tripeptide aldehyde GYKI-14766 (D-MePhe-Pro-Arg-H) synthesized by Bajusz et al. in 1975 is a specific, reversible thrombin… 
Review
1993
Review
1993
Chemistry and biology of the peptide anticoagulant D-MePhe-Pro-Arg-H (GYKI-14766).
The story of D-MePhe-Pro-Arg-H goes back to the mid-70s when its parent compound D-Phe-Pro-Arg-H (GYKI-14166) was discovered1,2. 
1993
1993
Chromogen-substrate assay--as a tool for monitoring a new thrombin inhibitor.
The N-methyl-D-phenylalanyl-L-prolyl-arginine-aldehyde sulfate tripeptide-aldehyde (GYKI-14766) is an anticoagulant with specific… 
1992
1992
Inhibition by D-MePhe-Pro-Arg-H (GYKI-14766) of Thrombus Growth in Experimental Models of Thrombosis
Summary The antithrombotic action of the highly effective synthetic thrombin inhibitor D-MePhe-Pro-Arg-H (GYKI-14766) was studied… 
1992
1992
In Vitro Inhibition of Blood Coagulation by Tripeptide Aldehydes - A Retrospective Screening Study Focused on the Stable D-MePhe-Pro-Arg-H · H2SO4
Summary A series of peptide aldehydes synthetized in our institute during the last 15 years were screened to detect their… 
Highly Cited
1990
Highly Cited
1990
Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H.
D-Phe-Pro-Arg-H sulfate (GYKI-14166) is a highly active and selective inhibitor of thrombin both in vitro and in vivo. Recent… 
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