Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Inhibition of thrombin and trypsin by tripeptide aldehydes.
- S. Bajusz, E. Barabás, P. Tolnay, E. Széll, D. Bagdy
- Chemistry, Medicine
- International journal of peptide and protein…
- 12 January 2009
Inhibitory effects of certain tripeptide aldehydes on both thrombin and trypsin have been found to be strongly substrate-dependent. These compounds should therefore be considered as inhibitors of the… Expand
[Effect of elastase on blood coagulation].
- D. Bagdy
- Chemistry, Biology
- Experientia
- 15 March 1959
Purified elastase prepared by adsorption on synthetic zeolite in proper concentrations causes the coagulation of blood. Elastase was found to have no direct coagulative action on purified fibrinogen.… Expand
Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H.
- S. Bajusz, E. Széll, +7 authors E. Tomori
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 June 1990
D-Phe-Pro-Arg-H sulfate (GYKI-14166) is a highly active and selective inhibitor of thrombin both in vitro and in vivo. Recent studies on the stability of D-Phe-Pro-Arg-H in neutral aqueous solution… Expand
In vitro inhibition of blood coagulation by tripeptide aldehydes--a retrospective screening study focused on the stable D-MePhe-Pro-Arg-H.H2SO4.
- D. Bagdy, E. Barabás, S. Bajusz, E. Széll
- Chemistry, Medicine
- Thrombosis and haemostasis
- 2 March 1992
A series of peptide aldehydes synthetized in our institute during the last 15 years were screened to detect their inhibitory effect on blood coagulation. Simple conventional clotting assays, platelet… Expand
Beta-2-microglobulin-specific autoantibodies cause platelet aggregation and interfere with ADP-induced aggregation.
- A. Falus, K. Merétey, +4 authors S. Bozsóky
- Chemistry, Medicine
- Clinical and experimental immunology
- 1982
The anti-platelet activity of beta-2-microglobulin (beta 2m) specific autoantibodies isolated from sera of patients with autoimmune diseases was tested in direct and ADP-induced aggregation assays.… Expand
Inhibition by D-MePhe-Pro-Arg-H (GYKI-14766) of thrombus growth in experimental models of thrombosis.
- D. Bagdy, G. Szabó, E. Barabás, S. Bajusz
- Medicine
- Thrombosis and haemostasis
- 3 August 1992
The antithrombotic action of the highly effective synthetic thrombin inhibitor D-MePhe-Pro-Arg-H (GYKI-14766) was studied in various models of experimental thrombosis. The compound administered to… Expand
In vivo anticoagulant and antiplatelet effect of D-Phe-Pro-Arg-H and D-MePhe-Pro-Arg-H.
- D. Bagdy, E. Barabás, G. Szabó, S. Bajusz, E. Széll
- Medicine
- Thrombosis and haemostasis
- 2 March 1992
D-Phe-Pro-Arg-H and D-MePhe-Pro-Arg-H synthetized in our institute were administered to mice, rats, rabbits and beagle dogs. The kinetics of the anticoagulant and antiplatelet effect was recorded by… Expand
Design and synthesis of peptide inhibitors of blood coagulations.
- S. Bajusz, E. Széll, E. Barabás, D. Bagdy
- Chemistry, Medicine
- Folia haematologica
- 1982
Inhibition of blood coagulation by peptide aldehydes has been studied. Amino acid sequences were assembled from the P1-P2 portion of the cleavage sites(s) of clotting factors and residues selected… Expand