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GW 678248
Known as:
GW-678248
, GW678248
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Nitriles
Sulfonamides
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Synthesis and biological evaluation of benzophenone derivatives as potential HIV-1 inhibitors.
Zhendong Song
,
Ping Wang
,
+7 authors
Xiaodong Ma
Medicinal chemistry
2017
Corpus ID: 40044700
BACKGROUND Although a number of agents can achieve high response in acquired immunodeficiency syndrome (AIDS) patients, safer and…
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2016
2016
Design, Synthesis, and Biological Evaluation of Novel 2‐(Pyridin‐3‐yloxy)acetamide Derivatives as Potential Anti‐HIV‐1 Agents
Boshi Huang
,
Xiao Li
,
+4 authors
Xinyong Liu
Chemical Biology and Drug Design
2016
Corpus ID: 35870011
Through a structure‐based molecular hybridization and bioisosterism approach, a series of novel 2‐(pyridin‐3‐yloxy)acetamide…
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Review
2016
Review
2016
Benzophenone Derivatives : a Novel Scaffold as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
Y. Ge
,
Jiasheng Xu
,
Zhendong Song
,
Xiaodong Ma
2016
Corpus ID: 13821655
Developing non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs) with improved drug resistance profiles is still a great…
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2010
2010
The disposition and metabolism of GW695634: A non-nucleoside reverse transcriptase inhibitor (NNRTi) for treatment of HIV/AIDS
M. de Serres
,
L. Moss
,
+4 authors
C. Serabjit-Singh
Xenobiotica; the fate of foreign compounds in…
2010
Corpus ID: 36789908
GW695634 is the prodrug of GW678248, a novel non-nucleoside reverse transcriptase inhibitor with potent antiviral activity…
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2010
2010
Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease
D. Jochmans
,
Maria Anders
,
+4 authors
B. Müller
Retrovirology
2010
Corpus ID: 5729652
BackgroundCurrent antiretroviral therapy against human immunodeficiency virus (HIV-1) reduces viral load and thereby prevents…
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Highly Cited
2006
Highly Cited
2006
Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor.
K. Romines
,
G. A. Freeman
,
+10 authors
L. Boone
Journal of Medicinal Chemistry
2006
Corpus ID: 36902312
Despite the progress of the past two decades, there is still considerable need for safe, efficacious drugs that target human…
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Highly Cited
2005
Highly Cited
2005
Antiviral Activity of GW678248, a Novel Benzophenone Nonnucleoside Reverse Transcriptase Inhibitor
R. Ferris
,
R. Hazen
,
+12 authors
L. Boone
Antimicrobial Agents and Chemotherapy
2005
Corpus ID: 3185496
ABSTRACT The compound GW678248 is a novel benzophenone nonnucleoside reverse transcriptase inhibitor (NNRTI). Preclinical…
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2005
2005
Anti-Human Immunodeficiency Virus Type 1 Activity of the Nonnucleoside Reverse Transcriptase Inhibitor GW678248 in Combination with Other Antiretrovirals against Clinical Isolate Viruses and In Vitro…
R. Hazen
,
R. Harvey
,
+9 authors
L. Boone
Antimicrobial Agents and Chemotherapy
2005
Corpus ID: 27109883
ABSTRACT GW678248, a novel nonnucleoside reverse transcriptase inhibitor, has been evaluated for anti-human immunodeficiency…
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