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GW 678248

Known as: GW-678248, GW678248 
National Institutes of Health

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2 relations

Broader (2)

NitrilesSulfonamides

Papers overview

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2017
2017
Synthesis and biological evaluation of benzophenone derivatives as potential HIV-1 inhibitors.
BACKGROUND Although a number of agents can achieve high response in acquired immunodeficiency syndrome (AIDS) patients, safer and… 
2016
2016
Design, Synthesis, and Biological Evaluation of Novel 2‐(Pyridin‐3‐yloxy)acetamide Derivatives as Potential Anti‐HIV‐1 Agents
Through a structure‐based molecular hybridization and bioisosterism approach, a series of novel 2‐(pyridin‐3‐yloxy)acetamide… 
Review
2016
Review
2016
Benzophenone Derivatives : a Novel Scaffold as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
Developing non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs) with improved drug resistance profiles is still a great… 
2010
2010
The disposition and metabolism of GW695634: A non-nucleoside reverse transcriptase inhibitor (NNRTi) for treatment of HIV/AIDS
GW695634 is the prodrug of GW678248, a novel non-nucleoside reverse transcriptase inhibitor with potent antiviral activity… 
2010
2010
Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease
BackgroundCurrent antiretroviral therapy against human immunodeficiency virus (HIV-1) reduces viral load and thereby prevents… 
Highly Cited
2006
Highly Cited
2006
Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor.
Despite the progress of the past two decades, there is still considerable need for safe, efficacious drugs that target human… 
Highly Cited
2005
Highly Cited
2005
Antiviral Activity of GW678248, a Novel Benzophenone Nonnucleoside Reverse Transcriptase Inhibitor
ABSTRACT The compound GW678248 is a novel benzophenone nonnucleoside reverse transcriptase inhibitor (NNRTI). Preclinical… 
2005
2005
Anti-Human Immunodeficiency Virus Type 1 Activity of the Nonnucleoside Reverse Transcriptase Inhibitor GW678248 in Combination with Other Antiretrovirals against Clinical Isolate Viruses and In Vitro…
ABSTRACT GW678248, a novel nonnucleoside reverse transcriptase inhibitor, has been evaluated for anti-human immunodeficiency… 
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