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GW 678248

Known as: GW-678248, GW678248 
 
National Institutes of Health

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2 relations

Broader (2)

NitrilesSulfonamides

Papers overview

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2016
2016
Design, Synthesis, and Biological Evaluation of Novel 2-(Pyridin-3-yloxy)acetamide Derivatives as Potential Anti-HIV-1 Agents.
Through a structure-based molecular hybridization and bioisosterism approach, a series of novel 2-(pyridin-3-yloxy)acetamide… Expand
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2016
2016
Synthesis and biological evaluation of benzophenone derivatives as potential HIV-1 inhibitors.
BACKGROUND Although a number of agents can achieve high response in acquired immunodeficiency syndrome (AIDS) patients, safer and… Expand
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Review
2016
Review
2016
Benzophenone Derivatives : a Novel Scaffold as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
Developing non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs) with improved drug resistance profiles is still a great… Expand
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2010
2010
The disposition and metabolism of GW695634: a non-nucleoside reverse transcriptase inhibitor (NNRTi) for treatment of HIV/AIDS.
GW695634 is the prodrug of GW678248, a novel non-nucleoside reverse transcriptase inhibitor with potent antiviral activity… Expand
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2010
2010
Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease
BackgroundCurrent antiretroviral therapy against human immunodeficiency virus (HIV-1) reduces viral load and thereby prevents… Expand
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2006
2006
Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor.
Despite the progress of the past two decades, there is still considerable need for safe, efficacious drugs that target human… Expand
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2005
2005
Anti-human immunodeficiency virus type 1 activity of the nonnucleoside reverse transcriptase inhibitor GW678248 in combination with other antiretrovirals against clinical isolate viruses and in vitro…
GW678248, a novel nonnucleoside reverse transcriptase inhibitor, has been evaluated for anti-human immunodeficiency virus… Expand
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2005
2005
Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor.
The compound GW678248 is a novel benzophenone nonnucleoside reverse transcriptase inhibitor (NNRTI). Preclinical assessment of… Expand
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2005
2005
Selection for Resistance against Clinical Isolate Viruses and In Vitro Combination with Other Antiretrovirals Transcriptase Inhibitor GW 678248 in 1 Activity of the Nonnucleoside Reverse Anti-Human…
10.1128/AAC.49.11.4465-4473.2005. 2005, 49(11):4465. DOI: Antimicrob. Agents Chemother. Romines, Joseph H. Chan and Lawrence R… Expand
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