Zhendong Song

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Adenine derivatives, in particular the scaffold bearing the acyclic nucleoside phosphonates (ANPS), possess significant antiviral and cytostatic activity. Till now, several effective adenine derivatives have been marketed for the treatment of HIV, HBV, CMV and other virus-infected diseases. These compounds are represented by tenofovir (PMPA), a medicine for(More)
Aiming at planar linkage mechanisms considering joint clearance effects, a modular approach based on the link group theory and the graph theory is proposed to improve modeling efficiency. The massless link model to simulate joint clearances provides possibility for using modular approach to analyze the clearance effects. Meanwhile, this approach highlights(More)
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