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GW 5074

Known as: GW-5074, GW5074 
National Institutes of Health

Papers overview

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2015
2015
DA-9801 promotes neurite outgrowth via ERK1/2-CREB pathway in PC12 cells.
In the present study, we examined the mechanisms underlying the effect of DA-9801 on neurite outgrowth. We found that DA-9801… 
2013
2013
Secondhand cigarette smoke exposure causes upregulation of cerebrovascular 5‐HT1B receptors via the Raf/ERK/MAPK pathway in rats
Cigarette smoke exposure increases the risk of stroke. Upregulation of 5‐hydroxytryptamine 1B (5‐HT1B) receptors is associated… 
Highly Cited
2010
Highly Cited
2010
Protein Farnesylation–Dependent Raf/Extracellular Signal–Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic β-Cells
OBJECTIVE Posttranslational prenylation (e.g., farnesylation) of small G-proteins is felt to be requisite for cytoskeletal… 
2010
2010
Raf-1 Kinase Regulates Smooth Muscle Contraction in the Rat Mesenteric Arteries
We investigated the potential role of Raf-1 kinase in mesenteric arterial contraction. Inhibitors of Raf-1 kinase, GW5074… 
2009
2009
Ultrasound stimulates NF‐κB activation and iNOS expression via the Ras/Raf/MEK/ERK signaling pathway in cultured preosteoblasts
It has been shown that ultrasound (US) stimulation accelerates fracture healing in the animal models and non‐operatively clinical… 
2007
2007
Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells.
We have previously shown that oridonin isolated from Rabdosia rubescens augmented apoptosis while inhibiting autophagy within 24… 
2006
2006
Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway.
Oridonin, isolated from Rabdosia rubescences, has been reported to exert cytotoxic effects on L929 cells. In this study, we… 
2006
2006
Chronic morphine-mediated adenylyl cyclase superactivation is attenuated by the Raf-1 inhibitor, GW5074.
Highly Cited
2003
Highly Cited
2003
Converging Protein Kinase Pathways Mediate Adenylyl Cyclase Superactivation upon Chronic δ-Opioid Agonist Treatment
Adenylyl cyclase (AC) superactivation is thought to play an important role in opioid tolerance, dependence, and withdrawal. In… 
Highly Cited
2002
Highly Cited
2002
Involvement of Raf-1 in chronic delta-opioid receptor agonist-mediated adenylyl cyclase superactivation.
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