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Caryophyllene sesquiterpenes from the marine-derived fungus Ascotricha sp. ZJ-M-5 by the one strain-many compounds strategy.
It can be concluded that modification of the culture media is still effective in the discovery of novel bioactive fungal secondary metabolites.
Three new acylated flavone C-glycosides from the flowers of Trollius chinensis
Three new flavone C-glycosides with the substitution of the unusual acyl were isolated from the antibacterial fraction of the aqueous extract of the flowers of Trollius chinensis by detailed analysis of the NMR and MS spectra.
Two new compounds from a marine-derived fungus Penicilliumoxalicum
Two new anthraquinones are isolated from a marine-derived fungus Penicillium oxalicum and the structures of these compounds were determined by spectroscopic methods.
A new cyclonerol derivative from a marine-derived fungus Ascotricha sp. ZJ-M-5
A new sesquiterpene, ascotrichic acid (1), was isolated from a marine-derived fungus Ascotricha sp., together with the other two known analogues, cyclonerodiol (2) and 10(Z)-cyclonerotriol (3). Its
Five New Triterpenoids from the Roots of Kadsura coccinea
A phytochemical investigation of an EtOH extract of the roots of Kadsura coccinea (Lem.) A. C. Sm. furnished five new lanostane-type triterpenoids, coccinone A (1), coccinone B (2), coccinone C (3),
Oridonin-induced A431 cell apoptosis partially through blockage of the Ras/Raf/ERK signal pathway.
It was found that the total tyrosine kinase activity was inhibited and the protein expressions of epidermal growth factor receptor (EGFR) and phosphorylated EGFR were decreased in oridonin-induced A431 cell apoptosis.
Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway
Taken together, oridonin induced apoptosis in A431 cells via mitochondrial pathway, activation of caspase-3 and inhibition of tyrosine kinase activities.
Penicitols A-C and penixanacid A from the mangrove-derived Penicillium chrysogenum HDN11-24.
Three new citrinin analogues, penicitols A-C (1-3), and one new xanthone derivative, penixanacid A (4), together with four known biogenetically related compounds (5-8), were discovered from the
Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells.
Autophagic level is significantly upregulated when A431 cells are pretreated with manumycin A (Ras specific inhibitor) compared with oridonin alone treatment, whereas cells precultured with GW5074 (Raf inhibitor) or PD98059 (ERK inhibitor) did not exhibit such an effect.
Oridonin inhibited the tyrosine kinase activity and induced apoptosis in human epidermoid carcinoma A431 cells.
This study investigated the mechanism involved in oridonin-induced cell death in human epidermoid carcinoma A431 cells, which overexpress epidermal growth factor receptor (EGFR) and exerted a potential inhibitory effect on the tyrosine kinase activity of A431 Cells.