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GUCY2C gene
Known as:
GUC2C
, heat stable enterotoxin receptor
, STAR
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This gene is involved in ligand-dependent cGMP synthase activity.
National Institutes of Health
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Related topics
Related topics
5 relations
GUCY2C protein, human
Ligand Binding
Receptor Signaling
Signal Transduction
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis
E. Blomain
,
J. Rappaport
,
+5 authors
S. Waldman
Cancer Biology & Therapy
2020
Corpus ID: 211070646
ABSTRACT Sporadic colorectal cancer initiates with mutations in APC or its degradation target β-catenin, producing TCF-dependent…
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2019
2019
TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C
Tara S. Abraham
,
J. Flickinger
,
S. Waldman
,
A. Snook
Journal of Immunology
2019
Corpus ID: 58617225
Characterizing self-tolerance mechanisms and their failure is critical to understand immune homeostasis, cancer immunity, and…
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2017
2017
GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.
Peng Li
,
E. Wuthrick
,
+7 authors
S. Waldman
Cancer Research
2017
Corpus ID: 4779136
High doses of ionizing radiation induce acute damage to epithelial cells of the gastrointestinal (GI) tract, mediating toxicities…
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Review
2016
Review
2016
GUCY2C ligand replacement to prevent colorectal cancer
E. Blomain
,
Amanda M. Pattison
,
S. Waldman
Cancer Biology & Therapy
2016
Corpus ID: 3650992
ABSTRACT Despite advances in screening and prevention strategies, colorectal cancer (CRC) remains the second-leading cause of…
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Review
2016
Review
2016
Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer
E. Blomain
,
D. Merlino
,
Amanda M. Pattison
,
A. Snook
,
S. Waldman
Molecular Pharmacology
2016
Corpus ID: 8503709
Obesity has emerged as a principal cause of mortality worldwide, reflecting comorbidities including cancer risk, particularly in…
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2015
2015
Abstract 2882: Calorie-induced silencing of the tumor suppressive guanylin-GUCY2C paracrine axis underlies colorectal cancer in obesity
E. Blomain
,
J. Lin
,
+5 authors
S. Waldman
2015
Corpus ID: 78203691
2014
2014
Association between GUC2C and ADHD: Evidence from both categorical and quantitative traits
Lu Liu
,
Haimei Li
,
Yi Wang
,
Li Yang
,
Q. Qian
,
Yufeng Wang
Psychiatry Research
2014
Corpus ID: 26735093
2014
2014
Guanylyl Cyclase C as Biomarker
P. S. Chang
,
T. Hyslop
,
S. Waldman
2014
Corpus ID: 73042943
Metastasis is the primary cause of death from colorectal cancer. In that context, overall survival and therapeutic response to…
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2009
2009
GUCY2C reverse transcriptase PCR to stage pN0 colorectal cancer patients
A. Mejia
,
S. Schulz
,
T. Hyslop
,
D. Weinberg
,
S. Waldman
Expert Review of Molecular Diagnostics
2009
Corpus ID: 39171708
The most important prognostic marker of survival and predictive marker of response to adjuvant chemotherapy in colon cancer…
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2009
2009
Abstract #4412: GUCY2C establishes lineage dependence in intestinal tumorigenesis through AKT
J. Lin
,
A. Snook
,
Peng Li
,
S. Schulz
,
G. Pitari
,
S. Waldman
2009
Corpus ID: 70735030
An evolving paradigm expanding the genetic basis of cancer suggests that tissue-specific developmental programs indelibly imprint…
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