Skip to search formSkip to main contentSkip to account menu

GSK343

National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

IndazolesPyridones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
EZH2抑制剂与吉非替尼联合应用在EGFR-TKIs耐药肺癌细胞中的作用研究
背景与目的 肺癌是危害身体健康的常见恶性肿瘤之一。随着表观遗传学的发展，研究者发现Zeste基因增强子同源物基因2（enhancer of Zeste homolog 2, EZH2）在肺癌中高表达且其表达量与预后息息相关，与此同时EZH2… 
2017
2017
[Therapeutic effect of enhancer of Zeste homolog 2 inhibitor GSK343 on periodontitis by regulating macrophage differentiation].
OBJECTIVE To explore the therapeutic effect of enhancer of Zeste homolog 2 (EZH2) inhibitor GSK343 on periodontitis by regulating… 
Review
2016
Review
2016
Novel strategies for molecular targeting to cancer
This editorial draws attention to the work published by CEPP in 2014–2015 on mechanisms underlying cancer drug resistance… 
2016
2016
EZH 2 inhibitors transcriptionally upregulate cytotoxic autophagy and cytoprotective unfolded protein response in human colorectal cancer cells
Enhancer of zeste homolog 2 (EZH2) has been emerged as novel anticancer target. Various EZH2 small-molecule inhibitors have been… 
2016
2016
Cigarette smoke alters the EZH2/DAB2IP expression in bronchial epithelial cells. A risk factor for lung cancer in COPD patients
Cigarette smoke is an environmental risk factor for COPD and Lung cancer, leading causes of morbidity and mortality worldwide. In… 
2015
2015
PO43TRI-METHYLATED HISTONE H3K27 LEVELS ARE ASSOCIATED WITH LOCATION, AGE AND SURVIVAL.
INTRODUCTION: Ependymoma is the second most common malignant paediatric tumour of the central nervous system, accounting for 6-12… 
2014
2014
S-Adenosyl-l-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells
The enhancer of zeste homolog 2 (EZH2) has emerged as a novel anticancer target. Various EZH2 inhibitors have been developed in… 
2014
2014
Loss of the Histone Demethylase UTX Contributes to Multiple Myeloma and Sensitizes Cells to EZH2 Inhibitors
Genetic alterations of epigenetic regulators have become a recurrent theme in hematological malignancies. In particular… 
2013
2013
EZH2 and BCL6 Cooperate To Create The Germinal Center B-Cell Phenotype and Induce Lymphomas Through Formation and Repression Of Bivalent Chromatin Domains
The EZH2 histone methyltransferase is the enzymatic core of the Polycomb repressor 2 (PRC2 complex), is highly upregulated in… 
2013
2013
3D culture adds an extra dimension to targeted epigenetic therapies
Histone methyltransferases (HMT) are chromatin modifiers that regulate the transcriptomic landscape in normal development as well… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)