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Background and Purpose— One class of poststroke restorative therapy focuses on promoting axon outgrowth by blocking myelin-based… Expand Introduction: One class of potential post-stroke restorative therapy focuses on promoting axon outgrowth by blocking myelin-based… Expand Myelin-associated glycoprotein (MAG) is an inhibitor of axon growth. MAG levels increase after stroke. GSK249320 is a monoclonal… Expand Background and Purpose— New insights into the brain’s ability to reorganize after injury are beginning to suggest novel… Expand Introduction Transcranial Magnetic Stimulation (TMS) is a neurophysiological tool capable of assessing the motor nervous system… Expand Background and Purpose— Restorative therapies have the potential to improve function and reduce disability after stroke with a… Expand GSK249320, a monoclonal antibody directed against myelin‐associated glycoprotein (MAG), is being developed for the enhancement of… Expand OBJECTIVE: Primary: examine safety and tolerability of GSK249320. Secondary: examine immunogenicity, pharmacokinetics, biomarkers… Expand