• Publications
  • Influence
Safety, Pharmacokinetic, and Functional Effects of the Nogo-A Monoclonal Antibody in Amyotrophic Lateral Sclerosis: A Randomized, First-In-Human Clinical Trial
TLDR
Safety, pharmacokinetics, and functional effects of ozanezumab, a humanized monoclonal antibody against Nogo-A were well tolerated and co-localization at the site of action was demonstrated, supporting future studies with ozaneZumab in ALS. Expand
The tremorolytic action of beta-adrenoceptor blockers in essential, physiological and isoprenaline-induced tremor is mediated by beta-adrenoceptors located in a deep peripheral compartment.
TLDR
It is proposed that the results indicate that the tremorolytic activity of beta-adrenoceptor blockers in essential, physiological and isoprenaline-induced tremor is exerted via the same beta 2- adrenoceptors located in a deep peripheral compartment which is thought to be in the muscle spindles. Expand
Essential tremor: a review.
  • B. Abila
  • Medicine
  • West African journal of medicine
  • 1991
TLDR
The condition is characterised by slowly progressive postural tremor of the arms and head without an identifiable organic cause and is often misdiagnosed as Parkinson's disease. Expand
Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study
TLDR
This large series of muscle biopsies from patients with ALS demonstrates neurogenic atrophy is a nearly uniform finding and that mild mitochondrial abnormalities and low-grade inflammation can be seen and do not rule out the diagnosis of ALS, and could lend support to the notion that ALS is a complex and heterogeneous disorder. Expand
First‐Time‐in‐Human Study With GSK249320, a Myelin‐Associated Glycoprotein Inhibitor, in Healthy Volunteers
TLDR
GSK249320, a monoclonal antibody directed against myelin‐associated glycoprotein (MAG), is being developed for the enhancement of recovery of function poststroke and was well tolerated at all doses, with AUC showing dose linearity. Expand
Effects of two antihistamines on chloroquine and histamine induced weal and flare in healthy African volunteers.
TLDR
It is concluded that histamine is unlikely to be the main mediator of chloroquine-induced weal and flare, and the findings are in consonance with the lack of significant effect of antihistamines on chloroquin-induced generalised pruritus. Expand
Safety, Pharmacokinetics, and Pharmacodynamics of Escalating Repeat Doses of GSK249320 in Patients With Stroke
TLDR
Modality-specific end points could be consistently measured in the first few days after stroke, and one of these, gait velocity, demonstrated a trend toward improvement with GSK249320 compared with placebo, suggesting that this first study of a monoclonal antibody to modulate the neurobiology of brain repair after stroke was generally well tolerated. Expand
Anticonvulsant effects of extracts of the west African black pepper, Piper guineense.
TLDR
The results indicate that the extract of P. guineense has prolonged anticonvulsant activity at doses which do not cause significant CNS depression. Expand
Urine methylhistamine concentrations before and after chloroquine in healthy black subjects.
TLDR
The findings suggest that histamine may be released bychloroquine, but it is unlikely to be the main cause of chloroquine-induced pruritus. Expand
Halofantrine-induced pruritus amongst subjects who itch to chloroquine.
TLDR
It is suggested that itcher to halofantrine may constitute a small group within the population of itchers to chloroquine and this may be of therapeutic importance. Expand
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