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GSG2 gene

Known as: HAPLOID GERM CELL-SPECIFIC NUCLEAR PROTEIN KINASE, germ cell associated 2, haspin, GSG2 
National Institutes of Health

Papers overview

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2020
2020
Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors.
2019
2019
HASPIN kinase mediates histone deacetylation to regulate oocyte meiotic maturation in pigs.
HASPIN kinase-catalyzed phosphorylation of histone H3 on threonine 3 (H3T3p) directs the activity and localization of chromosomal… 
2017
2017
Anti-Melanoma Activities of Haspin Inhibitor CHR-6494 Deployed as a Single Agent or in a Synergistic Combination with MEK Inhibitor
Background: Melanoma is a heterogeneous malignancy that presents an immense challenge in therapeutic development. Recent… 
2017
2017
The Mitotic Protein Kinase Haspin and Its Inhibitors
Haspin is an atypical serine/threonine protein kinase essential to mitosis. Unlike other protein kinases, its kinase domain does… 
2016
2016
Kinase Gene Expression Profiling of Metastatic Clear Cell Renal Cell Carcinoma Tissue Identifies Potential New Therapeutic Targets
Kinases are therapeutically actionable targets. Kinase inhibitors targeting vascular endothelial growth factor receptors (VEGFR… 
2016
2016
Genetic Variation in the Testis-Specific HASPIN Gene Encoding a Serine/Threonine Protein Kinase in Infertile Japanese Males
HASPIN is a serine/threonine protein kinase predominantly expressed during spermatogenesis and localized in the nucleus. The… 
2015
2015
Chromosome segregation regulation in human zygotes: altered mitotic histone phosphorylation dynamics underlying centromeric targeting of the chromosomal passenger complex.
STUDY QUESTION Are the kinase feedback loops that regulate activation and centromeric targeting of the chromosomal passenger… 
2011
2011
DNA methylation-dependent modulator of Gsg2/Haspin gene expression.
The Gsg2 (Haspin) gene encodes a serine/threonine protein kinase and is predominantly expressed in haploid germ cells. In… 
2011
2011
Methylation-mediated control of aurora kinase B and Haspin with epigenetically modified histone H3 N-terminal peptides.
2001
2001
Nested genomic structure of haploid germ cell specific haspin gene.
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