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Involvement of the mt1 melatonin receptor in human breast cancer.
Two putative melatonin receptors have been described including the cell surface G-protein-linked receptors, mt1 and MT2, and the nuclear retinoic orphan receptor alpha (RORalpha). The mt1 receptor,Expand
IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1.
It is found that IL-6 promotes the invasion of U87 MG human glioma cells but not in U343 cells, and the STAT3 pathway and fascin-1 may play crucial roles in the invasiveness of U 87MG cells promoted by IL- 6. Expand
MT1 melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells
Melatonin inhibits the proliferation of estrogen receptor alpha (ERα)-positive (MCF-7), but not ERα-negative (MDA-MB-231) breast cancer cells. Here, we assessed the effect of MT1 melatonin receptorExpand
Multifactorial ERβ and NOTCH1 control of squamous differentiation and cancer.
A link between transcriptional control of NOTCH1 expression and the estrogen response in keratinocytes is identified, with implications for differentiation therapy of squamous cancer. Expand
The Retinoid-Related Orphan Receptor RORα Promotes Keratinocyte Differentiation via FOXN1
The results point to RORα as a novel node in the keratinocyte differentiation network and further suggest that the identification of ROR α ligands may prove useful for treating skin disorders that are associated with abnormal keratinocytes differentiation, including cancer. Expand
Modulation of intracellular calcium and calmodulin by melatonin in MCF‐7 human breast cancer cells
Melatonin's effects on the Ca2+/CaM signaling pathway may play an important role in mediating the growth‐inhibitory effect of melatonin on MCF‐7 human breast cancer cells. Expand
MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells.
The involvement of the MT(1) melatonin receptor in mediation of melatonin effects on growth-suppression and gene-modulation in breast cancer cells is suggested. Expand
Neutral endopeptidase inhibits neuropeptide-mediated transactivation of the insulin-like growth factor receptor-Akt cell survival pathway.
Data show that the neuropeptides ET-1 and bombesin stimulate ligand-independent activation of the IGF-IR, which results in Akt activation, and that this cross-communication between GPCR and IGF- IR signaling is inhibited by NEP. Expand
Myeloid-Derived Suppressor Cells: Paradoxical Roles in Infection and Immunity
The biological and immunological aspects of MDSCs, including their generation, distribution, trafficking and the factors involved in their activation, expansion, suppressive functions, and interplay between M DSCs and regulatory T cells are recapitulate, with a focus on the perspectives of infection and inflammation. Expand
Differential responsiveness of MCF‐7 human breast cancer cell line stocks to the pineal hormone, melatonin
Findings suggest that not only may these differences have some impact on the cells’ estrogen‐response pathway, but also that the primary growth‐inhibitory effects of melatonin are transduced through the membrane‐associated G‐protein coupled mt1 melatonin receptor. Expand