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GPX4 gene

Known as: PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE, PHGPx, GLUTATHIONE PEROXIDASE 4 
National Institutes of Health

Related topics

Related topics

3 relations
GLUTATHIONE PEROXIDASESMCP genephospholipid-hydroperoxide glutathione peroxidase

Papers overview

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Highly Cited
2004
Highly Cited
2004
Protective effect of phospholipid hydroperoxide glutathione peroxidase (PHGPx) against lipid peroxidation in mussels Perna perna exposed to different metals.
Highly Cited
2002
Highly Cited
2002
Salt stress induces up-regulation of an efficient chloroplast antioxidant system in the salt-tolerant wild tomato species Lycopersicon pennellii but not in the cultivated species.
The response of the chloroplastic antioxidant system of the cultivated tomato Lycopersicon esculentum (Lem) and its wild salt… 
Highly Cited
2001
Highly Cited
2001
Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross‐linking during sperm maturation
A 34 kD selenoprotein purified from rat testis was identified as a specific sperm nuclei glutathione peroxidase (snGPx) with… 
Highly Cited
2001
Highly Cited
2001
Saccharomyces cerevisiae Expresses Three Phospholipid Hydroperoxide Glutathione Peroxidases*
The GPX1, GPX2, andGPX3 genes of Saccharomyces cerevisiaehave been reported previously to encode glutathione peroxidases (GPxs… 
Highly Cited
1999
Highly Cited
1999
mRNA stability and selenocysteine insertion sequence efficiency rank gastrointestinal glutathione peroxidase high in the hierarchy of selenoproteins.
The recently described gastrointestinal glutathione peroxidase (GI-GPx) is the fourth member of the family of the selenoenzymes… 
Highly Cited
1998
Highly Cited
1998
Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation
Selenium deficiency is known to be associated with male infertility, and the selenoprotein PHGPx has been shown to increase in… 
Highly Cited
1997
Highly Cited
1997
Interleukin-1-induced nuclear factor kappa B activation is inhibited by overexpression of phospholipid hydroperoxide glutathione peroxidase in a human endothelial cell line.
Oxygen radicals are commonly accepted mediators in the tumour necrosis factor-mediated nuclear factor kappa B (NF kappa B… 
Highly Cited
1995
Highly Cited
1995
Probing the presumed catalytic triad of selenium-containing peroxidases by mutational analysis of phospholipid hydroperoxide glutathione peroxidase (PHGPx).
Single and double site mutants affecting the presumed catalytic centre of the selenoenzyme PHGPx were subjected to functional… 
Highly Cited
1994
Highly Cited
1994
Selenium Deficiency Triggering Intractable Seizures
Two children with severe neurodevelopmental retardation and elevated liver function tests developed intractable seizures during… 
Highly Cited
1992
Highly Cited
1992
Phospholipid hydroperoxide glutathione peroxidase of rat testis. Gonadotropin dependence and immunocytochemical identification.
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