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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functionalExpand
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents anExpand
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour types, and in engineered cells overexpressing oncogenic RAS. Yet, its relevance in non-transformedExpand
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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.
Ferroptosis is a form of regulated necrotic cell death controlled by glutathione peroxidase 4 (GPX4). At present, mechanisms that could predict sensitivity and/or resistance and that may be exploitedExpand
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Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function
ABSTRACT Oxygen radicals regulate many physiological processes, such as signaling, proliferation, and apoptosis, and thus play a pivotal role in pathophysiology and disease development. There are atExpand
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Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.
Oxidative stress in conjunction with glutathione depletion has been linked with various acute and chronic degenerative disorders, yet the molecular mechanisms have remained unclear. In contrast toExpand
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The oxidative stress-inducible cystine/glutamate antiporter, system xc−: cystine supplier and beyond
The oxidative stress-inducible cystine/glutamate exchange system, system xc−, transports one molecule of cystine, the oxidized form of cysteine, into cells and thereby releases one molecule ofExpand
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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.
Enigmatic lipid peroxidation products have been claimed as the proximate executioners of ferroptosis-a specialized death program triggered by insufficiency of glutathione peroxidase 4 (GPX4). UsingExpand
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FSP1 is a glutathione-independent ferroptosis suppressor
Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids1,2. To date, ferroptosis has been thought to be controlled only by the phospholipidExpand
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Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross‐linking during sperm maturation
A 34 kD selenoprotein purified from rat testis was identified as a specific sperm nuclei glutathione peroxidase (snGPx) with similar properties to phospholipid hydroperoxide glutathione peroxidaseExpand
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