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Thyrostimulin, a putative glycoprotein hormone, comprises the subunits GPA2 and GPB5 and activates the TSH receptor (TSHR). The… Expand BackgroundThe three vertebrate pituitary glycoprotein hormones (GPH) are heterodimers of a common α and a specific β subunit. In… Expand The heterodimer thyrostimulin, comprised of two novel glycoprotein hormone subunits GPA2 and GPB5, activates the TSH receptor. To… Expand Ascidians, which are the closest phylogenetic relatives to vertebrates, lack a distinct pituitary gland, which is the major… Expand The acquisition of a hypothalamic-pituitary axis was a seminal event in vertebrate evolution leading to the neuroendocrine… Expand The vertebrate glycoprotein hormones (GpHs), gonadotropins and thyrotropin, are heterodimers composed of a common alpha- and… Expand BackgroundCystine-knot (cys-knot) structure is found in a rather large number of secreted proteins and glycoproteins belonging to… Expand Thyrostimulin is a heterodimeric hormone composed of GPA2 and GPB5, and shares the thyroid-stimulating hormone receptor (TSHR… Expand Corticotroph-derived glycoprotein hormone (CGH), also referred to as thyrostimulin, is a noncovalent heterodimer of glycoprotein… Expand Two glycoprotein hormone subunits, (glycoprotein hormone alpha2-subunit GPA2) and (glycoprotein hormone beta5-subunit GPB5) have… Expand