GNA12 gene

Known as: G protein subunit alpha 12, gep, GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-12 
This gene plays a role in signal transduction and cytoskeletal remodeling.
National Institutes of Health

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Environment-to-Cell CommunicationG Protein-Coupled Receptor SignalingGNA12 protein, humanGTP Binding
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Papers overview

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2017
2017
c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells
Abstract: GNA12 is the α subunit of a heterotrimeric G protein that possesses oncogenic potential. Activated GNA12 also promotes… (More)
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2016
2016
Preeclampsia is Associated with Decreased Methylation of the GNA12 Promoter.
Preeclampsia, characterized by high blood pressure, albuminuria and other systemic disorders, is a serious complication during… (More)
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2014
2014
Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and −8, and matrix metalloproteinase-2
BACKGROUND Recent studies on the involvement of the G12 family of heterotrimeric G proteins (Gα12 and Gα13, the products of the… (More)
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Highly Cited
2012
Highly Cited
2012
Network-Assisted Investigation of Combined Causal Signals from Genome-Wide Association Studies in Schizophrenia
With the recent success of genome-wide association studies (GWAS), a wealth of association data has been accomplished for more… (More)
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2012
2012
miRNA-Mediated Relationships between Cis-SNP Genotypes and Transcript Intensities in Lymphocyte Cell Lines
In metazoans, miRNAs regulate gene expression primarily through binding to target sites in the 3' UTRs (untranslated regions) of… (More)
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2010
2010
Genetic mapping of a novel hypotrichosis locus to chromosome 7p21.3–p22.3 in a Pakistani family and screening of the candidate genes
Hereditary hypotrichosis is a heterogeneous group of inherited hair loss disorders characterized by diffused or localized… (More)
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2009
2009
Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure.
Oral squamous cell carcinoma (OSCC) is a world health problem and is associated with exposure to different risk factors. In the… (More)
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2008
2008
Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II.
1. There are two types of familial hyperaldosteronism (FH): FH-I and FH-II. FH-I is caused by a hybrid CYP11B1/CYP11B2 gene… (More)
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2008
2008
RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits.
The heterotrimeric G-protein pathway controls numerous cellular processes, including proliferation, differentiation, migration… (More)
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1988
1988
Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human.
A variety of genes have been identified that specify the synthesis of the components of guanine nucleotide-binding proteins (G… (More)
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