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GNA12 gene
Known as:
G protein subunit alpha 12
, gep
, GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-12
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This gene plays a role in signal transduction and cytoskeletal remodeling.
National Institutes of Health
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Related topics
Related topics
5 relations
Environment-to-Cell Communication
G Protein-Coupled Receptor Signaling
GNA12 protein, human
GTP Binding
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells
Udhaya Kumari Udayappan
,
P. Casey
Molecules
2017
Corpus ID: 21792061
GNA12 is the α subunit of a heterotrimeric G protein that possesses oncogenic potential. Activated GNA12 also promotes prostate…
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2016
2016
GEP oncogene promotes cell proliferation through YAP activation in ovarian cancer
H. Yagi
,
K. Asanoma
,
T. Ohgami
,
A. Ichinoe
,
K. Sonoda
,
K. Kato
Oncogene
2016
Corpus ID: 6993051
G-protein-coupled receptors (GPCRs) and their ligands function in the progression of human malignancies. Gα12 and Gα13, encoded…
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Highly Cited
2016
Highly Cited
2016
miR-564 acts as a dual inhibitor of PI3K and MAPK signaling networks and inhibits proliferation and invasion in breast cancer
M. Mutlu
,
Özge Saatci
,
+5 authors
Ö. Sahin
Scientific Reports
2016
Corpus ID: 4538453
Dysregulation of PI3K and MAPK pathways promotes uncontrolled cell proliferation, apoptotic inhibition and metastasis. Individual…
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2016
2016
Preeclampsia is Associated with Decreased Methylation of the GNA12 Promoter
W. Ye
,
L. Shen
,
Y. Xiong
,
Yun Zhou
,
H. Gu
,
Zu-jing Yang
Annals of Human Genetics
2016
Corpus ID: 26917537
Preeclampsia, characterized by high blood pressure, albuminuria and other systemic disorders, is a serious complication during…
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2014
2014
Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and −8, and matrix metalloproteinase-2
Crystal Y. Chia
,
Udhaya Kumari
,
P. Casey
Journal of Molecular Signaling
2014
Corpus ID: 16192020
Background Recent studies on the involvement of the G12 family of heterotrimeric G proteins (Gα12 and Gα13, the products of the…
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Highly Cited
2012
Highly Cited
2012
Network-Assisted Investigation of Combined Causal Signals from Genome-Wide Association Studies in Schizophrenia
P. Jia
,
Lily Wang
,
A. Fanous
,
C. Pato
,
T. Edwards
,
Zhongming Zhao
PLoS Comput. Biol.
2012
Corpus ID: 11511044
With the recent success of genome-wide association studies (GWAS), a wealth of association data has been accomplished for more…
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Highly Cited
2009
Highly Cited
2009
Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure.
S. Cheong
,
G. Chandramouli
,
+8 authors
J. Gutkind
Oral Oncology
2009
Corpus ID: 25854782
2008
2008
EXAMINATION OF CHROMOSOME 7p22 CANDIDATE GENES RBaK, PMS2 AND GNA12 IN FAMILIAL HYPERALDOSTERONISM TYPE II
Y.W.A. Jeske,
,
A. So
,
+6 authors
M. Stowasser
Clinical and Experimental Pharmacology and…
2008
Corpus ID: 13265069
1 There are two types of familial hyperaldosteronism (FH): FH‐I and FH‐II. FH‐I is caused by a hybrid CYP11B1/CYP11B2 gene…
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2008
2008
RGS22, A Novel Testis-Specific Regulator of G-protein Signaling Involved in Human and Mouse Spermiogenesis along with GNA12/13 Subunits1
Yanqiu Hu
,
Jun Xing
,
+7 authors
J. Sha
Biology of Reproduction
2008
Corpus ID: 25100186
Abstract The heterotrimeric G-protein pathway controls numerous cellular processes, including proliferation, differentiation…
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Highly Cited
1988
Highly Cited
1988
Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human.
C. Blatt
,
P. Eversole-Cire
,
+7 authors
R. Reed
Proceedings of the National Academy of Sciences…
1988
Corpus ID: 10425220
A variety of genes have been identified that specify the synthesis of the components of guanine nucleotide-binding proteins (G…
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