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GMI-1070

Known as: Pan-Selectin Antagonist GMI-1070 
A synthetic, glycomimetic molecule and pan-selectin antagonist, with potential use in a vaso-occlusive crisis. Upon administration, GMI-1070 prevents… Expand
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Glycolipids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
E-selectin ligand complexes adopt an extended high-affinity conformation
E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early… Expand
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Highly Cited
2015
Highly Cited
2015
Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use.
Treatment of vaso-occlusive crises (VOC) or events in sickle cell disease (SCD) remains limited to symptom relief with opioids… Expand
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Highly Cited
2012
Highly Cited
2012
P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment.
Interactions between multiple myeloma (MM) cells and the BM microenvironment play a critical role in the pathogenesis of MM and… Expand
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2011
2011
Inhibition of E-Selectin Inflammatory Function by the Glycomimetic GMI-1070
Abstract 851 Introduction: E-selectin expression by endothelium plays dual roles in inflammation by supporting slow rolling and… Expand
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2011
2011
Pan-Selectin Antagonist, GMI-1070 Decreases Venous Thrombosis in a Mouse Model,
Abstract 3273 Introduction: E- and P-selectin have structural similarities and both facilitate white blood cell tethering on… Expand
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Highly Cited
2010
Highly Cited
2010
GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice.
Leukocyte adhesion in the microvasculature influences blood rheology and plays a key role in vaso-occlusive manifestations of… Expand
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2010
2010
GMI-1070, a Pan-Selectin Inhibitor: Safety and PK In a Phase 1/2 Study In Adults with Sickle Cell Disease
Abstract 1632 GMI-1070 is a pan-selectin inhibitor that targets E-, P-, and L-selectins and has shown activity in multiple animal… Expand
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2010
2010
Effects of GMI-1070, a Pan-Selectin Inhibitor, on Leukocyte Adhesion In Sickle Cell Disease: Results From a Phase 1/2 Study
Abstract 262 Adhesion molecules are critically involved in the pathophysiology of sickle cell disease (SCD). A growing body of… Expand
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2010
2010
Effects of Selectin Antagonist GMI-1070 on the Activation State of Leukocytes In Sickle Cell Patients Not In Crisis
Methods Effects of Selectin Antagonist GMI-1070 on the Activation State of Leukocytes in Sickle Cell Patients not in Crisis SI… Expand
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2007
2007
GMI-1070: A Small Pan-Selectin Antagonist That Inhibits Leukocyte Adhesion and Migration in Multple Disease Models In Vivo.
Rational design of glycomimetic inhibitors based on the bioactive conformation of functional carbohydrates provides new… Expand
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