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GMI-1070

Known as: Pan-Selectin Antagonist GMI-1070 
A synthetic, glycomimetic molecule and pan-selectin antagonist, with potential use in a vaso-occlusive crisis. Upon administration, GMI-1070 prevents… 
National Institutes of Health

Related topics

Related topics

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Broader (1)

Glycolipids

Papers overview

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Review
2019
Review
2019
Lectin antagonists in infection, immunity, and inflammation.
2016
2016
E-selectin ligand complexes adopt an extended high-affinity conformation
E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early… 
Highly Cited
2015
Highly Cited
2015
Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use.
Treatment of vaso-occlusive crises (VOC) or events in sickle cell disease (SCD) remains limited to symptom relief with opioids… 
Review
2013
Review
2013
Contemporary drug therapies for multiple myeloma.
Multiple myeloma (MM) is an incurable disease characterized by the proliferation of plasma cells. The survival in MM patients has… 
Highly Cited
2012
Highly Cited
2012
P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment.
Interactions between multiple myeloma (MM) cells and the BM microenvironment play a critical role in the pathogenesis of MM and… 
Review
2011
Review
2011
E-Selectin Ligands as Mechanosensitive Receptors on Neutrophils in Health and Disease
Application of mechanical force to bonds between selectins and their ligands is a requirement for these adhesion receptors to… 
2011
2011
Inhibition of E-Selectin Inflammatory Function by the Glycomimetic GMI-1070
Abstract 851 Introduction: E-selectin expression by endothelium plays dual roles in inflammation by supporting slow rolling and… 
Highly Cited
2010
Highly Cited
2010
GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice.
Leukocyte adhesion in the microvasculature influences blood rheology and plays a key role in vaso-occlusive manifestations of… 
2010
2010
Effects of GMI-1070, a Pan-Selectin Inhibitor, on Leukocyte Adhesion In Sickle Cell Disease: Results From a Phase 1/2 Study
Abstract 262 Adhesion molecules are critically involved in the pathophysiology of sickle cell disease (SCD). A growing body of… 
2010
2010
GMI-1070, a Pan-Selectin Inhibitor: Safety and PK In a Phase 1/2 Study In Adults with Sickle Cell Disease
Abstract 1632 GMI-1070 is a pan-selectin inhibitor that targets E-, P-, and L-selectins and has shown activity in multiple animal… 
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