FAQ

GMI-1070

Known as: Pan-Selectin Antagonist GMI-1070 
A synthetic, glycomimetic molecule and pan-selectin antagonist, with potential use in a vaso-occlusive crisis. Upon administration, GMI-1070 prevents… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2010-2015
012320102015

Related topics

Related topics

1 relation

Broader (1)

Glycolipids

Related mentions per year

Related mentions per year

1951-2018
1960198020002020
GMI-1070
Glycolipids

Papers overview

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2016
2016
E-selectin ligand complexes adopt an extended high-affinity conformation
E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early… (More)
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2016
2016
Biomarkers and recent advances in the management and therapy of sickle cell disease [version 1; referees: 2 approved]
Although production of hemoglobin S, the genetic defect that causes sickle cell disease (SCD), directly affects only red blood… (More)
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2015
2015
Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use.
Treatment of vaso-occlusive crises (VOC) or events in sickle cell disease (SCD) remains limited to symptom relief with opioids… (More)
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Review
2013
Review
2013
Contemporary drug therapies for multiple myeloma.
Multiple myeloma (MM) is an incurable disease characterized by the proliferation of plasma cells. The survival in MM patients has… (More)
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2012
2012
P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment.
Interactions between multiple myeloma (MM) cells and the BM microenvironment play a critical role in the pathogenesis of MM and… (More)
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2012
2012
LYMPHOID NEOPLASIA P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment
Interactions between multiple myeloma (MM) cells and the BM microenvironment play a critical role in the pathogenesis of MM and… (More)
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Review
2012
Review
2012
Heparin mimetics.
Explorations of the therapeutic potential of heparin mimetics, anionic compounds that are analogues of glycosaminoglycans (GAGs… (More)
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2011
2011
Aptamer therapy for SCD?
In this issue of Blood, Gutsaeva et al describe an aptamer with high affinity for murine P-selectin and its efficacy in… (More)
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Highly Cited
2010
Highly Cited
2010
GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice.
Leukocyte adhesion in the microvasculature influences blood rheology and plays a key role in vaso-occlusive manifestations of… (More)
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2010
2010
Mightier than the sickle cell.
Thrombosis and ELISA optical density values in hospitalized patients with heparin-induced thrombocytopenia. from patients with… (More)
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