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GMI-1070
Known as:
Pan-Selectin Antagonist GMI-1070
A synthetic, glycomimetic molecule and pan-selectin antagonist, with potential use in a vaso-occlusive crisis. Upon administration, GMI-1070 prevents…
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National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Glycolipids
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Lectin antagonists in infection, immunity, and inflammation.
Joscha Meiers
,
Eike Siebs
,
E. Zahorska
,
A. Titz
Current opinion in chemical biology
2019
Corpus ID: 201785844
2016
2016
E-selectin ligand complexes adopt an extended high-affinity conformation
R. C. Preston
,
R. Jakob
,
F. Binder
,
C. P. Sager
,
B. Ernst
,
T. Maier
Journal of molecular cell biology
2016
Corpus ID: 2634095
E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early…
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Highly Cited
2015
Highly Cited
2015
Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use.
M. Telen
,
T. Wun
,
+8 authors
H. Thackray
Blood
2015
Corpus ID: 206931608
Treatment of vaso-occlusive crises (VOC) or events in sickle cell disease (SCD) remains limited to symptom relief with opioids…
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Review
2013
Review
2013
Contemporary drug therapies for multiple myeloma.
P. de la Puente
,
A. Azab
Drugs of today
2013
Corpus ID: 23289322
Multiple myeloma (MM) is an incurable disease characterized by the proliferation of plasma cells. The survival in MM patients has…
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Highly Cited
2012
Highly Cited
2012
P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment.
A. Azab
,
Phong Quang
,
+16 authors
I. Ghobrial
Blood
2012
Corpus ID: 16047325
Interactions between multiple myeloma (MM) cells and the BM microenvironment play a critical role in the pathogenesis of MM and…
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Review
2011
Review
2011
E-Selectin Ligands as Mechanosensitive Receptors on Neutrophils in Health and Disease
S. Chase
,
J. Magnani
,
S. Simon
Annals of Biomedical Engineering
2011
Corpus ID: 17963062
Application of mechanical force to bonds between selectins and their ligands is a requirement for these adhesion receptors to…
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2011
2011
Inhibition of E-Selectin Inflammatory Function by the Glycomimetic GMI-1070
S. Simon
,
S. Chase
,
H. Thackray
,
J. Magnani
,
T. Wun
2011
Corpus ID: 78198484
Abstract 851 Introduction: E-selectin expression by endothelium plays dual roles in inflammation by supporting slow rolling and…
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Highly Cited
2010
Highly Cited
2010
GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice.
Jungshan Chang
,
J. Patton
,
A. Sarkar
,
B. Ernst
,
J. Magnani
,
P. Frenette
Blood
2010
Corpus ID: 206887729
Leukocyte adhesion in the microvasculature influences blood rheology and plays a key role in vaso-occlusive manifestations of…
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2010
2010
Effects of GMI-1070, a Pan-Selectin Inhibitor, on Leukocyte Adhesion In Sickle Cell Disease: Results From a Phase 1/2 Study
T. Wun
,
L. M. Castro
,
+5 authors
H. Thackray
2010
Corpus ID: 57227557
Abstract 262 Adhesion molecules are critically involved in the pathophysiology of sickle cell disease (SCD). A growing body of…
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2010
2010
GMI-1070, a Pan-Selectin Inhibitor: Safety and PK In a Phase 1/2 Study In Adults with Sickle Cell Disease
L. Styles
,
T. Wun
,
+5 authors
H. Thackray
2010
Corpus ID: 208382582
Abstract 1632 GMI-1070 is a pan-selectin inhibitor that targets E-, P-, and L-selectins and has shown activity in multiple animal…
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