Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

GMI-1070

Known as: Pan-Selectin Antagonist GMI-1070 
A synthetic, glycomimetic molecule and pan-selectin antagonist, with potential use in a vaso-occlusive crisis. Upon administration, GMI-1070 prevents… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2015
Highly Cited
2015
Treatment of vaso-occlusive crises (VOC) or events in sickle cell disease (SCD) remains limited to symptom relief with opioids… Expand
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Interactions between multiple myeloma (MM) cells and the BM microenvironment play a critical role in the pathogenesis of MM and… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2011
2011
Abstract 851 Introduction: E-selectin expression by endothelium plays dual roles in inflammation by supporting slow rolling and… Expand
Is this relevant?
2011
2011
Abstract 3273 Introduction: E- and P-selectin have structural similarities and both facilitate white blood cell tethering on… Expand
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Leukocyte adhesion in the microvasculature influences blood rheology and plays a key role in vaso-occlusive manifestations of… Expand
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
2010
2010
Abstract 1632 GMI-1070 is a pan-selectin inhibitor that targets E-, P-, and L-selectins and has shown activity in multiple animal… Expand
Is this relevant?
2010
2010
Abstract 262 Adhesion molecules are critically involved in the pathophysiology of sickle cell disease (SCD). A growing body of… Expand
Is this relevant?
2010
2010
Methods Effects of Selectin Antagonist GMI-1070 on the Activation State of Leukocytes in Sickle Cell Patients not in Crisis SI… Expand
  • figure 2
Is this relevant?
2007
2007
Rational design of glycomimetic inhibitors based on the bioactive conformation of functional carbohydrates provides new… Expand
Is this relevant?