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GMI-1070

Known as: Pan-Selectin Antagonist GMI-1070 
A synthetic, glycomimetic molecule and pan-selectin antagonist, with potential use in a vaso-occlusive crisis. Upon administration, GMI-1070 prevents… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early… Expand
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Highly Cited
2015
Highly Cited
2015
Treatment of vaso-occlusive crises (VOC) or events in sickle cell disease (SCD) remains limited to symptom relief with opioids… Expand
2014
2014
Introduction: The pan-selectin antagonist rivipansel (GMI-1070) reduced intravascular arrest of red/white blood cell aggregates… Expand
Highly Cited
2012
Highly Cited
2012
Interactions between multiple myeloma (MM) cells and the BM microenvironment play a critical role in the pathogenesis of MM and… Expand
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2011
2011
Abstract 851 Introduction: E-selectin expression by endothelium plays dual roles in inflammation by supporting slow rolling and… Expand
Highly Cited
2010
Highly Cited
2010
Leukocyte adhesion in the microvasculature influences blood rheology and plays a key role in vaso-occlusive manifestations of… Expand
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2010
2010
Abstract 1632 GMI-1070 is a pan-selectin inhibitor that targets E-, P-, and L-selectins and has shown activity in multiple animal… Expand
2010
2010
Abstract 262 Adhesion molecules are critically involved in the pathophysiology of sickle cell disease (SCD). A growing body of… Expand
2008
2008
Acute vaso-occlusion (VOC) in patients with sickle cell disease (SCD) induces intense pain arising from organ damage and is the… Expand
2007
2007
Rational design of glycomimetic inhibitors based on the bioactive conformation of functional carbohydrates provides new… Expand