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GMI-1070

Known as: Pan-Selectin Antagonist GMI-1070 
A synthetic, glycomimetic molecule and pan-selectin antagonist, with potential use in a vaso-occlusive crisis. Upon administration, GMI-1070 prevents… 
National Institutes of Health

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Related topics

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Broader (1)

Glycolipids

Papers overview

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2012
2012
occlusions in sickle cell mice GMI-1070, a novel pan-selectin antagonist, reverses acute vascular
http://bloodjournal.hematologylibrary.org/content/116/10/1779.full.html Updated information and services can be found at: (358… 
2012
2012
Pan-Selectin Antagonist GMI-1070 Affects Biomarkers of Adhesion, Activation and the Coagulation Cascade in Sickle Cell Adults At Steady State
Abstract 87 Introduction: Engagement of selectins by their ligands leads to cellular activation and adhesion and plays a role in… 
2011
2011
Inhibition of E-Selectin Inflammatory Function by the Glycomimetic GMI-1070
Abstract 851 Introduction: E-selectin expression by endothelium plays dual roles in inflammation by supporting slow rolling and… 
2011
2011
Aptamer therapy for SCD?
In this issue of Blood , Gutsaeva et al describe an aptamer with high affinity for murine P-selectin and its efficacy in… 
2010
2010
GMI-1070, a Pan-Selectin Inhibitor: Safety and PK In a Phase 1/2 Study In Adults with Sickle Cell Disease
Abstract 1632 GMI-1070 is a pan-selectin inhibitor that targets E-, P-, and L-selectins and has shown activity in multiple animal… 
2010
2010
Effects of GMI-1070, a Pan-Selectin Inhibitor, on Leukocyte Adhesion In Sickle Cell Disease: Results From a Phase 1/2 Study
Abstract 262 Adhesion molecules are critically involved in the pathophysiology of sickle cell disease (SCD). A growing body of… 
2010
2010
Effects of Selectin Antagonist GMI-1070 on the Activation State of Leukocytes In Sickle Cell Patients Not In Crisis
Methods Effects of Selectin Antagonist GMI-1070 on the Activation State of Leukocytes in Sickle Cell Patients not in Crisis SI… 
Review
2009
Review
2009
Safety, Tolerability and Pharmacokinetics of GMI-1070, a Pan-Selectin Inhibitor for Treatment of Vaso-Occlusive Crisis: Single and Multiple Dose Studies in Healthy Volunteers.
Abstract 1526 Poster Board I-549 Introduction GMI-1070 is a pan-selectin inhibitor which targets E-, P-, and L-selectin, and has… 
2008
2008
Effects of Pan-Selectin Antagonist GMI-1070 on the Treatment of Vaso-Occlusion in Sickle Cell Mice
Acute vaso-occlusion (VOC) in patients with sickle cell disease (SCD) induces intense pain arising from organ damage and is the… 
2007
2007
GMI-1070: A Small Pan-Selectin Antagonist That Inhibits Leukocyte Adhesion and Migration in Multple Disease Models In Vivo.
Rational design of glycomimetic inhibitors based on the bioactive conformation of functional carbohydrates provides new… 
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