J. Patton

Publications214
h-index51
Citations8,886
Highly Influential Citations564
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Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG)
In April 2008, a nucleotide-sequence-based, complete genome classification system was developed for group A rotaviruses (RVs). This system assigns a specific genotype to each of the 11 genome… Expand
  • 723
  • 64
Full Genome-Based Classification of Rotaviruses Reveals a Common Origin between Human Wa-Like and Porcine Rotavirus Strains and Human DS-1-Like and Bovine Rotavirus Strains
ABSTRACT Group A rotavirus classification is currently based on the molecular properties of the two outer layer proteins, VP7 and VP4, and the middle layer protein, VP6. As reassortment of all the 11… Expand
  • 601
  • 55
Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments
Recently, a classification system was proposed for rotaviruses in which all the 11 genomic RNA segments are used (Matthijnssens et al. in J Virol 82:3204–3219, 2008). Based on nucleotide identity… Expand
  • 539
  • 50
Group A Human Rotavirus Genomics: Evidence that Gene Constellations Are Influenced by Viral Protein Interactions
ABSTRACT Group A human rotaviruses (HRVs) are the major cause of severe viral gastroenteritis in infants and young children. To gain insight into the level of genetic variation among HRVs, we… Expand
  • 130
  • 21
Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3.
  • Mario Barro, J. Patton
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 15 March 2005
IFN regulatory factor 3 (IRF3), a constitutively expressed protein localizing largely to the cytoplasm, is a primary effector of the innate immune response. Infection can trigger the phosphorylation,… Expand
  • 217
  • 19
Rotavirus NSP1 Inhibits Expression of Type I Interferon by Antagonizing the Function of Interferon Regulatory Factors IRF3, IRF5, and IRF7
ABSTRACT Secretion of interferon (IFN) by virus-infected cells is essential for activating autocrine and paracrine pathways that promote cellular transition to an antiviral state. In most mammalian… Expand
  • 164
  • 18
Rotavirus Replication: Plus-Sense Templates for Double-Stranded RNA Synthesis Are Made in Viroplasms
ABSTRACT Rotavirus plus-strand RNAs not only direct protein synthesis but also serve as templates for the synthesis of the segmented double-stranded RNA (dsRNA) genome. In this study, we identified… Expand
  • 191
  • 18
  • PDF
Genetic Analyses Reveal Differences in the VP7 and VP4 Antigenic Epitopes between Human Rotaviruses Circulating in Belgium and Rotaviruses in Rotarix and RotaTeq
ABSTRACT Two live-attenuated rotavirus group A (RVA) vaccines, Rotarix (G1P[8]) and RotaTeq (G1-G4, P[8]), have been successfully introduced in many countries worldwide, including Belgium. The… Expand
  • 118
  • 15
Full Genome-Based Classification of Rotaviruses Reveals Common Origin
Laboratory of Clinical & Epidemiological Virology, Department of Microbiology & Immunology, 7 Rega Institute for Medical Research, University of Leuven, Leuven, Belgium 1 ; Vaccine & 8 Biologics… Expand
  • 81
  • 15
Characterization of rotavirus replication intermediates: a model for the assembly of single-shelled particles.
The segmented double-stranded (ds)RNA genome of the rotaviruses is replicated asymmetrically with viral mRNA serving as the template for minus-strand RNA synthesis. To identify intermediate… Expand
  • 136
  • 10