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Evolution of adverse changes in stored RBCs
- E. Bennett-Guerrero, T. Veldman, +8 authors T. McMahon
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 23 October 2007
Recent studies have underscored questions about the balance of risk and benefit of RBC transfusion. A better understanding of the nature and timing of molecular and functional changes in stored RBCs… Expand
Definitions of the phenotypic manifestations of sickle cell disease
Sickle cell disease (SCD) is a pleiotropic genetic disorder of hemoglobin that has profound multiorgan effects. The low prevalence of SCD (∼100,000/US) has limited progress in clinical, basic, and… Expand
Pulmonary hypertension associated with sickle cell disease: Clinical and laboratory endpoints and disease outcomes
- L. De Castro, Jude C Jonassaint, F. Graham, A. Ashley-Koch, M. Telen
- American journal of hematology
- 1 January 2008
Screening for pulmonary hypertension (pHTN) has not yet become routine in sickle cell disease (SCD), despite clinical evidence of its high prevalence and associated mortality. Our objectives are to… Expand
Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance.
Erythrocytes carrying a variant hemoglobin allele (HbS), which causes sickle cell disease and resists infection by the malaria parasite Plasmodium falciparum. The molecular basis of this resistance,… Expand
Adherence to hydroxyurea therapy in children with sickle cell anemia.
OBJECTIVES To assess adherence to hydroxyurea therapy in children with sickle cell anemia (SCA), evaluate the association between adherence and hematologic profile, and identify barriers and… Expand
microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease.
Although individuals with homozygous sickle cell disease (HbSS) share the same genetic mutation, the severity and manifestations of this disease are extremely heterogeneous. We have previously shown… Expand
The Genomic Analysis of Erythrocyte microRNA Expression in Sickle Cell Diseases
Background Since mature erythrocytes are terminally differentiated cells without nuclei and organelles, it is commonly thought that they do not contain nucleic acids. In this study, we have… Expand
An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease.
- E. Klings, R. Machado, +17 authors M. Gladwin
- American journal of respiratory and critical care…
- 15 March 2014
BACKGROUND In adults with sickle cell disease (SCD), an increased tricuspid regurgitant velocity (TRV) measured by Doppler echocardiography, an increased serum N-terminal pro-brain natriuretic… Expand
Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion.
The vasoocclusive crisis is the major clinical feature of sickle cell anemia, which is believed to be initiated or sustained by sickle (SS) red blood cell (RBC) adhesion to the vascular wall. SS… Expand
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
The Trans-Omics for Precision Medicine (TOPMed) program seeks to elucidate the genetic architecture and disease biology of heart, lung, blood, and sleep disorders, with the ultimate goal of improving… Expand