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GLPG0187

Known as: Integrin Receptor Antagonist GLPG0187 
A small molecule integrin receptor antagonist (IRA) with potential antineoplastic activity. Upon administration, GLPG0187 binds to and blocks the… Expand
National Institutes of Health

Papers overview

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2016
2016
Glioblastoma is the most common and aggressive form of intrinsic brain tumor. Transforming growth factor (TGF)-β represents a… Expand
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2015
2015
SummaryBackground Integrin signaling is an attractive target for anti-cancer treatment. GLPG0187 is a broad spectrum integrin… Expand
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2015
2015
IntroductionIncreased expression of αv integrins is frequently associated with tumor cell adhesion, migration, invasion and… Expand
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2015
2015
Micrometastasis is a barrier to the development of effective cancer therapies for prostate cancer metastasis to bone. The… Expand
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2014
2014
Integrins regulate cellular adhesion and transmit signals important for cell survival, proliferation and motility. They are… Expand
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2011
2011
Acquisition of an invasive phenotype by cancer cells is a requirement for bone metastasis. Transformed epithelial cells can… Expand
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2010
2010
Introduction : GLPG0187, a small molecule integrin antagonist with nanomolar affinity for the RGD-integrin receptors αvβ1, αvβ3… Expand
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