GLPG0187

Known as: Integrin Receptor Antagonist GLPG0187 
A small molecule integrin receptor antagonist (IRA) with potential antineoplastic activity. Upon administration, GLPG0187 binds to and blocks the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2011-2016
0120112016

Papers overview

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2016
2016
Glioblastoma is the most common and aggressive form of intrinsic brain tumor. Transforming growth factor (TGF)-β represents a… (More)
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2015
2015
Background Integrin signaling is an attractive target for anti-cancer treatment. GLPG0187 is a broad spectrum integrin receptor… (More)
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2015
2015
Micrometastasis is a barrier to the development of effective cancer therapies for prostate cancer metastasis to bone. The… (More)
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2015
2015
Increased expression of αv integrins is frequently associated with tumor cell adhesion, migration, invasion and metastasis, and… (More)
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2014
2014
Integrins regulate cellular adhesion and transmit signals important for cell survival, proliferation and motility. They are… (More)
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2011
2011
Acquisition of an invasive phenotype by cancer cells is a requirement for bone metastasis. Transformed epithelial cells can… (More)
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