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GLI2 wt Allele

Known as: THP, GLI2, GLI-Kruppel Family Member GLI2 wt Allele 
Human GLI2 wild-type allele is located in the vicinity of 2q14 and is approximately 200 kb in length. This allele, which encodes zinc finger protein… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Aberrant activation of Hedgehog (HH) signaling is implicated in many human cancers. Classical HH signaling is characterized by… Expand
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Highly Cited
2003
Highly Cited
2003
Diminished Sonic Hedgehog (Shh) signaling is associated with the most common forebrain defect in humans, holoprosencephaly (HPE… Expand
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Highly Cited
2003
Highly Cited
2003
Gli proteins regulate the transcription of Hedgehog (Hh) target genes. Genetic studies in mouse have shown that Gli1 is not… Expand
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Highly Cited
2003
Highly Cited
2003
Sonic hedgehog (Shh) directs the development of ventral cell fates, including floor plate and V3 interneurons, in the mouse… Expand
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Highly Cited
2002
Highly Cited
2002
The Shh signaling pathway is required in many mammalian tissues for embryonic patterning, cell proliferation and differentiation… Expand
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Highly Cited
2001
Highly Cited
2001
In mice, three Gli genes are thought to mediate sonic hedgehog (Shh) signaling collectively. Mis-expression studies and analysis… Expand
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Highly Cited
2001
Highly Cited
2001
Pax3 is a paired box transcription factor expressed during somitogenesis that has been implicated in initiating the expression of… Expand
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Highly Cited
1998
Highly Cited
1998
Induction of the floor plate at the ventral midline of the neural tube is one of the earliest events in the establishment of… Expand
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Highly Cited
1998
Highly Cited
1998
Floor plate cells at the midline of the neural tube are specified by high-level activity of Sonic hedgehog (Shh) secreted by… Expand
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Highly Cited
1998
Highly Cited
1998
Within the developing vertebrate nervous system, it is not known how progenitor cells interpret the positional information… Expand
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