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GLI2 protein, human

Known as: THP2 protein, human, Tax helper protein 2, human, TRE-binding protein 2, human 
Zinc finger protein GLI2 (1586 aa, ~168 kDa) is encoded by the human GLI2 gene. This protein plays a role in embryonic development and… 
National Institutes of Health

Related topics

Related topics

13 relations
CYS2-HIS2 Zinc FingersCell NucleusDNA-Binding ProteinsGLI2 gene

Broader (2)

Kruppel-Like Transcription FactorsNuclear Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Inhibition of the Hedgehog signaling pathway suppresses cell proliferation by regulating the Gli2/miR-124/AURKA axis in human glioma cells.
Multiple lines of evidence indicate that aberrant activation of Hedgehog (Hh) signaling plays an important role in tumorigenesis… 
2017
2017
Research on the function and related mechanism of P27 gene in the intervertebral disc degeneration of mice
This study aims to investigate the function and related mechanism of P27 gene in intervertebral disc (IVD) degeneration of mice… 
2014
2014
Abstract 467: New molecular model identifying the critical role of the GLI2 oncogene in human colonic epithelial cell (HCEC) transformation
Colorectal cancer, comprising 85% sporadic non-hereditary tumors, is the third in cancer incidence and the second leading cause… 
2012
2012
Morphoproteomics provides support for TGF-β pathway signaling in the osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis.
Langerhans cell histiocytosis (LCH) has a challenging and still unclear pathogenesis. A body of literature points to impaired… 
2012
2012
Analysis of Wnt and Hedgehog Pathways Regulating Protein Kinases CK1 and CK2 in Acute Myeloid Leukemia Cells and Stem Cells: Correlation with the Expression of Wnt and Hedgehog Targets and Biological…
Abstract 2501 Background. Leukemia stem cells (LSC) constitute the reservoir of acute and chronic leukemias, from which the… 
2011
2011
PF-04449913 Reverts Multi Drug Resistance (MDR) by a Strong Down-Regulation of ABCA2 and BCL2 on Leukemia Stem Cells in Phase I Acute Myeloid Leukemia and Chronic Myeloid Leukemia Treated Patients
Abstract 1429 The development of resistance against chemotherapy remains one of the major challenges in the clinical management… 
2011
2011
Expression of Gli2, a Downstream Mediator of the Activated Hedgehog Pathway, Represents a Negative Prognostic Marker in AML,
Abstract 3535 The cancer and leukaemia stem cell hypothesis was first proposed over 40 years ago. This hypothesis suggests that… 
2010
2010
Varying phenotypes in swine versus murine transgenic models constitutively expressing the same human Sonic hedgehog transcriptional activator, K5-HGLI2ΔN
This study was undertaken to characterize the effects of constitutive expression of the hedgehog transcriptional activator, Gli2… 
2008
2008
GLI2 Transcriptional Cascade During Mouse Fetal Lung Development
OF THESIS Gli2 Transcriptional Cascade During Mouse Fetal Lung Development By Martin Edward Rutter PhD., 2008, Institute of… 
2003
2003
Expression of the GLI2 oncogene and its isoforms in human basal cell carcinoma
Summary Background Mutations of the patched (Ptc) gene, a developmental regulator implicated in the signalling pathway via sonic… 
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