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GGTI 2147

Known as: GGTI-2147, GGTI2147, geranylgeranyl transferase inhibitor-2147 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

ImidazolesLeucine
analogs & derivatives

Papers overview

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2015
2015
Inhibiting geranylgeranyltransferase I activity decreases spine density in central nervous system
Geranylgeranyltransferase I (GGT), a protein prenyltransferase, is responsible for the posttranslational lipidation of Rho… 
Review
2011
Review
2011
Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches.
2010
2010
Down-regulation of RhoA is involved in the cytotoxic action of lipophilic statins in HepG2 cells.
2010
2010
Characterization of the in vitro activity of AZD3409, a novel prenyl transferase inhibitor
PurposeAZD3409 is a novel DPTI that has potent activity against both FTase and GGTase-1. The in vitro inhibition profile of… 
2010
2010
Mitochondrial Function / Dysfunction in Health and Disease Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic-cells : evidence for regulation by Rac 1
Subasinghe W, Syed I, Kowluru A. Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic… 
Highly Cited
2003
Highly Cited
2003
Mastoparan-induced insulin secretion from insulin-secreting betaTC3 and INS-1 cells: evidence for its regulation by Rho subfamily of G proteins.
Mastoparan, a tetradecapeptide from wasp venom, stimulates insulin secretion from the islet beta-cells, presumably via activation… 
2003
2003
Novel Roles for the Rho Subfamily of GTP‐Binding Proteins in Succinate‐Induced Insulin Secretion from βTC3 Cells: Further Evidence in Support of the Succinate Mechanism of Insulin Release
We have previously demonstrated regulatory roles for Rho subfamily of G‐proteins in glucose‐ and calcium‐induced insulin… 
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