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Oxaliplatin-induced neuropathy in the rat: Involvement of oxalate in cold hyperalgesia but not mechanical allodynia
TLDR
The involvement of oxalate in oxaliplatin‐induced cold hyperalgesia but not mechanical allodynia is investigated, and usefulness of prophylactic treatments with calcium and magnesium on the acute peripheral neuropathy is suggested. Expand
Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder.
TLDR
Findings suggest that amantadine could be a useful drug for the treatment of OCD. Expand
First-pass metabolism of omeprazole in rats.
TLDR
It is suggested that omeprazole undergoes a first-pass metabolism in the intestinal mucosa and/or lumen, as well as in the liver, and that the major contribution to the dose-dependent increase in bioavailability is a saturation of the first- pass metabolism inThe liver. Expand
Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats
TLDR
Results indicated that spinal NR2B-containing NMDA receptors are involved in the oxaliplatin-induced mechanical allodynia in rats, and nitric oxide synthase as a downstream target of NMDA receptor was examined. Expand
Protection by a radical scavenger edaravone against cisplatin-induced nephrotoxicity in rats.
TLDR
Repeated injection of edaravone reversed the cisplatin-induced elevation of blood urea nitrogen and creatinine, and morphological changes in a dose-dependent manner, and suggest that the clinically available radical scavenger edarvone is potentially useful for the prevention of cisplarin-induced renal toxicity. Expand
Involvement of Substance P in Peripheral Neuropathy Induced by Paclitaxel but Not Oxaliplatin
TLDR
The results suggest that substance P is involved in paclitaxel-induced neuropathy, and the mechanism of its action is clearly different from that of oxaliplatin. Expand
Characterization of Histamine Release from the Rat Hypothalamus as Measured by In Vivo Microdialysis
TLDR
The results suggest that both HA‐N‐methyltransferase and H3 autoreceptors are involved in maintaining a constant level of extracellular HA and that their blockade effectively results in a higher activity level of the endogenous histaminergic system in the CNS. Expand
Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene
TLDR
It is indicated that blood concentrations, liver function, graft weight, and polymorphism in the ABCB1 gene are important factors in tacrolimus-induced neurotoxicity. Expand
A simple and simultaneous determination of acyclovir and ganciclovir in human plasma by high-performance liquid chromatography.
TLDR
A simple high-performance liquid chromatographic method was developed for the simultaneous determination of the therapeutic levels of acyclovir and ganciclovir in human plasma and is applicable to therapeutic monitoring during antiviral medication. Expand
Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms.
TLDR
It is suggested that aripiprazole may be a useful drug for the treatment of obsessive-compulsive disorder, and that it inhibits the marble-burying behavior via 5-HT1A receptor-independent mechanisms. Expand
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