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GEN1 protein, human

Known as: EC 3.1.-.-, Gen Endonuclease Homolog 1, Flap Endonuclease GEN Homolog 1 
Flap endonuclease GEN homolog 1 (908 aa, ~103 kDa) is encoded by the human GEN1 gene. This protein plays a role in homologous recombination and DNA… Expand
National Institutes of Health

Related topics

Related topics

15 relations
APEX2 protein, humanCell NucleusDNA Repair EndonucleaseDNA Replication
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Broader (2)

EsterasesHolliday Junction Resolvases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Resolution of single and double Holliday junction recombination intermediates by GEN1
Significance Holliday junction resolvases are required for the resolution of recombination intermediates to ensure proper… Expand
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2012
2012
A Novel Role of Human Holliday Junction Resolvase GEN1 in the Maintenance of Centrosome Integrity
The maintenance of genomic stability requires accurate genome replication, repair of DNA damage, and the precise segregation of… Expand
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Highly Cited
2010
Highly Cited
2010
The Caenorhabditis elegans Homolog of Gen1/Yen1 Resolvases Links DNA Damage Signaling to DNA Double-Strand Break Repair
DNA double-strand breaks (DSBs) can be repaired by homologous recombination (HR), which can involve Holliday junction (HJ… Expand
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2009
2009
The search for a human Holliday junction resolvase.
  • Stephen C West
  • Biochemical Society transactions
  • 2009
    • Corpus ID: 206153627
Four-way DNA intermediates, known as Holliday junctions, are formed during mitotic and meiotic recombination, and their efficient… Expand
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