GEN1 protein, human

Known as: EC 3.1.-.-, Gen Endonuclease Homolog 1, Flap Endonuclease GEN Homolog 1

Flap endonuclease GEN homolog 1 (908 aa, ~103 kDa) is encoded by the human GEN1 gene. This protein plays a role in homologous recombination and DNA… (More)

National Institutes of Health

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2009-2017

Papers overview

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2017

Resolution of single and double Holliday junction recombination intermediates by GEN1.

Rajvee Shah Punatar, María José Polo Martín, Haley D. M. Wyatt, Ying Wai Chan, Stephen C West
Proceedings of the National Academy of Sciences…
2017

Genetic recombination provides an important mechanism for the repair of DNA double-strand breaks. Homologous pairing and strand… (More)

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2012

A Novel Role of Human Holliday Junction Resolvase GEN1 in the Maintenance of Centrosome Integrity

Min Gao, Jannie M Rendtlew Danielsen, +6 authors Yun-Gui Yang
PloS one
2012

The maintenance of genomic stability requires accurate genome replication, repair of DNA damage, and the precise segregation of… (More)

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2010

The Caenorhabditis elegans Homolog of Gen1/Yen1 Resolvases Links DNA Damage Signaling to DNA Double-Strand Break Repair

Aymeric P. Bailly, Alasdair D. J. Freeman, +5 authors Anton Gartner
PLoS genetics
2010

DNA double-strand breaks (DSBs) can be repaired by homologous recombination (HR), which can involve Holliday junction (HJ… (More)

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2009

The search for a human Holliday junction resolvase.

Stephen C West
Biochemical Society transactions
2009

Four-way DNA intermediates, known as Holliday junctions, are formed during mitotic and meiotic recombination, and their efficient… (More)

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GEN1 protein, human

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