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GE 2770

Known as: GE-2270, GE2270 
 
National Institutes of Health

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1 relation
GE 2270 A

Papers overview

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2013
2013
Capturing linear intermediates and C-terminal variants during maturation of the thiopeptide GE2270.
Thiopeptides are ribosomally synthesized, posttranslationally modified peptides with potent activity against Gram-positives… Expand
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2011
2011
Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
4-Aminothiazolyl analogues of the antibiotic natural product GE2270 A (1) were designed, synthesized, and optimized for their… Expand
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2011
2011
4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding.
4-Aminothiazolyl analogues of the antibacterial natural product GE2270 A (1) were designed, synthesized, and evaluated for gram… Expand
2011
2011
In Vitro and In Vivo Activities of Novel, Semisynthetic Thiopeptide Inhibitors of Bacterial Elongation Factor Tu
ABSTRACT Recently, we identified aminothiazole derivatives of GE2270 A. These novel semisynthetic congeners, like GE2270 A… Expand
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2008
2008
Concise total synthesis of the thiazolyl peptide antibiotic GE2270 A.
The potent antibiotic thiazolylpeptide GE2270 A was synthesized starting from N-tert-butyloxycarbonyl protected valine in a… Expand
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2006
2006
Synthesis and configurational assignment of the amino alcohol in the eastern fragment of the GE2270 antibiotics by regio- and stereoselective addition of 2-metalated 4-bromothiazoles to alpha-chiral…
A synthesis of the eastern fragment of the thiazole peptide GE2270 A (1) has been developed. The synthetic approach relies on the… Expand
1997
1997
Targeted screening for elongation factor Tu binding antibiotics.
The development of a screen targeted to antibiotics which bind elongation factor Tu (EF-Tu) is described. The method was based on… Expand
Highly Cited
1991
Highly Cited
1991
Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization.
A novel antibiotic, GE2270 A, was isolated from the fermentation broth of a strain of Planobispora rosea. The product was found… Expand
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Highly Cited
1991
Highly Cited
1991
New antibiotic that acts specifically on the GTP‐bound form of elongation factor Tu.
The new thiazolyl peptide antibiotic GE2270 A, isolated from Planobispora rosea strain ATCC 53773, is shown to inhibit bacterial… Expand
1991
1991
Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. II. Structure elucidation.
GE2270 A, produced by Planobispora rosea ATCC 53773, inhibits Gram-positive bacteria and anaerobes by acting on the bacterial… Expand
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