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GE 2770

Known as: GE-2270, GE2270 
National Institutes of Health

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1 relation
GE 2270 A

Papers overview

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2014
2014
Heterologous Expression of the Thiopeptide Antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor Requires Deletion of Ribosomal Genes from the Expression Construct
GE2270 is a thiopeptide antibiotic generated by extensive posttranslational modifications of a ribosomally generated precursor… 
2013
2013
Capturing linear intermediates and C-terminal variants during maturation of the thiopeptide GE2270.
2011
2011
Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
4-Aminothiazolyl analogues of the antibiotic natural product GE2270 A (1) were designed, synthesized, and optimized for their… 
2011
2011
4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding.
4-Aminothiazolyl analogues of the antibacterial natural product GE2270 A (1) were designed, synthesized, and evaluated for gram… 
2008
2008
Concise total synthesis of the thiazolyl peptide antibiotic GE2270 A.
The potent antibiotic thiazolylpeptide GE2270 A was synthesized starting from N-tert-butyloxycarbonyl protected valine in a… 
2006
2006
Synthesis and configurational assignment of the amino alcohol in the eastern fragment of the GE2270 antibiotics by regio- and stereoselective addition of 2-metalated 4-bromothiazoles to alpha-chiral…
A synthesis of the eastern fragment of the thiazole peptide GE2270 A (1) has been developed. The synthetic approach relies on the… 
1993
1993
In vitro antimicrobial activity of a new antibiotic, MDL 62,879 (GE2270 A)
MDL 62,879 (GE2270 A) is a new peptide antibiotic that inhibits protein synthesis through an interaction with elongation factor… 
Highly Cited
1991
Highly Cited
1991
Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization.
A novel antibiotic, GE2270 A, was isolated from the fermentation broth of a strain of Planobispora rosea. The product was found… 
1991
1991
Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. II. Structure elucidation.
GE2270 A, produced by Planobispora rosea ATCC 53773, inhibits Gram-positive bacteria and anaerobes by acting on the bacterial… 
Highly Cited
1991
Highly Cited
1991
New antibiotic that acts specifically on the GTP‐bound form of elongation factor Tu.
The new thiazolyl peptide antibiotic GE2270 A, isolated from Planobispora rosea strain ATCC 53773, is shown to inhibit bacterial… 
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