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The complete atomic structure of the large ribosomal subunit at 2.4 A resolution.
The crystal structure of the large ribosomal subunit from Haloarcula marismortui is determined at 2.4 angstrom resolution, and it includes 2833 of the subunit's 3045 nucleotides and 27 of its 31 proteins. Expand
The structural basis of ribosome activity in peptide bond synthesis.
It is established that the ribosome is a ribozyme and the catalytic properties of its all-RNA active site are addressed and the mechanism of peptide bond synthesis appears to resemble the reverse of the acylation step in serine proteases. Expand
Crystal structure of the sodium–potassium pump
The X-ray crystal structure of the pig renal Na+,K+-ATPase with two rubidium ions bound (as potassium congeners) in an occluded state in the transmembrane part of the α-subunit is presented. Expand
Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension
Exome sequencing of zona glomerulosa–like APAs identifies nine with somatic mutations in either ATP1A1, encoding the Na+/K+ ATPase α1 subunit, or CACNA1D, encoding Cav1.3, which caused inward leak currents under physiological conditions and induced a shift of voltage-dependent gating to more negative voltages, suppressed inactivation or increased currents. Expand
Crystal Structure of the Ternary Complex of Phe-tRNAPhe, EF-Tu, and a GTP Analog
The overall shape of the ternary complex is similar to that of the translocation factor, EF-G-GDP, and this suggests a novel mechanism involving “molecular mimicry” in the translational apparatus. Expand
The structures of four macrolide antibiotics bound to the large ribosomal subunit.
- J. Hansen, J. A. Ippolito, N. Ban, P. Nissen, P. Moore, T. Steitz
- Biology, Medicine
- Molecular cell
- 1 July 2002
Crystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16-membered macrolide antibiotics carbomycin A, spiramycin, and tylosin and a 15-membered macrolide,… Expand
Crystal structure of a copper-transporting PIB-type ATPase
The structure of a PIB-ATPase, a Legionella pneumophila CopA Cu+-ATpase, in a copper-free form, is presented, as determined by X-ray crystallography at 3.2 Å resolution, and indicates a three-stage copper transport pathway involving several conserved residues. Expand
The atomic structure of P-type ATPases in different conformations, together with ample mutagenesis evidence, has provided detailed insights into the pumping mechanism by these biological nanomachines. Expand
Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM
- J. Sengupta, J. Nilsson, R. Gursky, C. Spahn, P. Nissen, J. Frank
- Biology, Medicine
- Nature Structural &Molecular Biology
- 1 October 2004
The results of a cryo-EM study of the 80S ribosome are presented that positively locate RACK1 on the head region of the 40S subunit, in the immediate vicinity of the mRNA exit channel. Expand
Placement of protein and RNA structures into a 5 Å-resolution map of the 50S ribosomal subunit
An electron-density map of the large 50S ribosomal subunit from the bacterium Haloarcula marismortui is calculated at 5.0 Å resolution by using phases derived from four heavy-atom derivatives, intercrystal density averaging and density-modification procedures. Expand