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Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta).
Exendin-4 is a 39 amino acid peptide isolated from the salivary secretions of the Gila monster (Heloderma suspectum). It shows 53% sequence similarity to glucagon-like peptide (GLP)-1. Unlike GLP-1,Expand
Regulation of the third member of the uncoupling protein family, UCP3, by cold and thyroid hormone.
Uncoupling protein (UCP1) is a transmembrane proton transporter present in the mitochondria of brown adipose tissue (BAT), a specialized tissue which functions in temperature homeostasis and energyExpand
A40926, a new glycopeptide antibiotic with anti-Neisseria activity.
In the course of a search for glycopeptide antibiotics having novel biological properties, we isolated A40926. Produced by an actinomycete of the genus Actinomadura, A40926 is a complex of four mainExpand
Determination of the acyl moieties of the antibiotic complex A40926 and their relation with the membrane lipids of the producer strain.
Structures of the fatty acid residues characterizing the various components of A40926 were determined by gas chromatography/mass spectrometry on the methyl esters obtained by methanolysis of theExpand
Structure of the murine immune response I-Aβ locus: Sequence of the I-Aβ gene and an adjacent β-chain second domain exon
Abstract The murine major histocompatibility complex I region encodes two class II antigens, I-A and I-E. From a mouse spleen DNA cosmid library of the b haplotype, we isolated a clone containing theExpand
Components of the GE2270 complex produced by Planobispora rosea ATCC 53773.
40 : 40 : 20, respectively. Factor T was purified by eluting with acetonitrile water 60 : 40. The purified antibiotics precipitated from the elutes after elimination of the acetonitrile underExpand
The Eb beta gene may have acted as the donor gene in a gene conversion‐like event generating the Abm 12 beta mutant.
At least two different class II histocompatibility antigens, I‐A and I‐E, are encoded by the murine major histocompatibility complex. Both types of class II antigens are composed of polypeptideExpand
Peptide aldehydes as inhibitors of HIV protease
We have recently shown that α‐MAPI, a peptidic aldehyde of microbial origin, inhibits the HIV protease with a potency comparable to pepstatin, having, differently from pepstatin, no activity on otherExpand
Inhibition of bacterial protein synthesis by elongation-factor-Tu-binding antibiotics MDL 62,879 and efrotomycin.
MDL 62,879 (formerly GE 2270 A) is a novel antibiotic active against Gram-positive bacteria by inhibiting protein synthesis. MDL 62,879 is not active against Gram-negative bacteria, but inhibitsExpand
In vitro antimicrobial activity of a new antibiotic, MDL 62,879 (GE2270 A).
MDL 62,879 (GE2270 A) is a new peptide antibiotic that inhibits protein synthesis through an interaction with elongation factor Tu. MDL 62,879 was very active against gram-positive clinical isolates,Expand
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