Skip to search formSkip to main contentSkip to account menu

GDP-dissociation inhibitor activity

Known as: GDI 
Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. [GOC:mah]
National Institutes of Health

Related topics

Related topics

1 relation
GDP binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins
We identify a role for the GDI-like solubilizing factor (GSF) PDEδ in modulating signalling through Ras family G proteins by… 
Highly Cited
2002
Highly Cited
2002
Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI.
The proper function of Rho GTPases requires precise spatial and temporal regulation of effector interactions. Integrin-mediated… 
Review
1998
Review
1998
The Rho small G protein family-Rho GDI system as a temporal and spatial determinant for cytoskeletal control.
Recent extensive studies have clarified the functions of the small G protein superfamily, which consists of the Ras, Rho, Rab… 
Highly Cited
1997
Highly Cited
1997
RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas.
GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases and may also be critical for the… 
Highly Cited
1996
Highly Cited
1996
RhoGDI-3 Is a New GDP Dissociation Inhibitor (GDI)
RhoB is a small GTP-binding protein highly homologous to the RhoA protein. While RhoA is known to regulate the assembly of focal… 
Highly Cited
1994
Highly Cited
1994
Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility.
Hepatocyte growth factor (HGF) induced motility of cultured mouse keratinocytes (308R cells). This HGF-induced cell motility was… 
Highly Cited
1994
Highly Cited
1994
rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells
Insulin and hepatocyte growth factor (HGF) induced morphologically different membrane rufflings in KB cells. Insulin-induced… 
Highly Cited
1993
Highly Cited
1993
Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility
Evidence is accumulating that rho p21, a ras p21-related small GTP-binding protein (G protein), regulates the actomyosin system… 
Highly Cited
1993
Highly Cited
1993
Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes.
The Ras-related small GTP-binding proteins are involved in diverse cellular events, including cell signaling, proliferation… 
Highly Cited
1990
Highly Cited
1990
Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP…
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)