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GCKR protein, human

Known as: GKRP protein, human, GKRP, Glucokinase Regulator 
Glucokinase regulatory protein (625 aa, ~69 kDa) is encoded by the human GCKR gene. This protein plays a role in the inhibition of carbohydrate… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (1)

Adaptor Proteins, Signal Transducing
Carbohydrate MetabolismCytoplasmic matrixGCKR geneGenes, Regulator

Papers overview

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2017
2017
Antidiabetic Disruptors of the Glucokinase-Glucokinase Regulatory Protein Complex Reorganize a Coulombic Interface.
The glucokinase regulatory protein (GKRP) plays an essential role in glucose homeostasis by acting as a competitive inhibitor of… 
2016
2016
Association Between a Glucokinase Regulator Genetic Variant and Metabolic Syndrome in Taiwanese Adolescents.
AIMS Variants of the glucokinase regulator (GCKR) gene are associated with metabolic syndrome (MetS). The present study explored… 
2014
2014
Discovery of Small-Molecule Glucokinase Regulatory Protein Modulators That Restore Glucokinase Activity
In the nuclei of hepatocytes, glucokinase regulatory protein (GKRP) modulates the activity of glucokinase (GK), a key regulator… 
2014
2014
Generalizability of genetic findings related to kidney function and albuminuria.
Nephrology has benefitted from several recent molecular genetics breakthroughs involving susceptibility to FSGS and focal global… 
2012
2012
Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis.
GK (glucokinase) is an enzyme central to glucose metabolism that displays positive co-operativity to substrate glucose. Small… 
2009
2009
Glucokinase and Glucokinase Regulatory Proteins are Functionally Coexpressed before Birth in the Rat Brain
Our previous description of functional glucokinase (GK) isoforms and their interactions with glucokinase regulatory protein (GKRP… 
2008
2008
Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
The rate of glucose phosphorylation in hepatocytes is determined by the subcellular location of glucokinase and by its… 
2008
2008
Activation and Translocation of Glucokinase in Rat Primary Hepatocytes Monitored by High Content Image Analysis
In the liver, glucokinase (GK) regulatory protein (GKRP) negatively modulates the metabolic enzyme GK by locking it in an… 
1997
1997
Molecular genetics of the human glucokinase regulator-fructokinase (GCKR-KHK) region of chromosome 2p23.
1996
1996
Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of Chromosome 2p23
The glucokinase regulator (GCKR) is a 65-kDa protein that inhibits glucokinase (hexokinase IV) in liver and pancreatic islet. The… 
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