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GART protein, human

Known as: EC 6.3.3.1, Phosphoribosylglycinamide Synthetase, Phosphoribosylamine--Glycine Ligase 
Trifunctional purine biosynthetic protein adenosine-3 (1010 aa, ~108 kDa) is encoded by the human GART gene. This protein is involved in the de novo… 
National Institutes of Health

Related topics

Related topics

10 relations
AnabolismCytoplasmic matrixEnzyme GeneGART gene

Broader (3)

Carbon-Nitrogen LigasesPhosphoribosylformylglycinamidine cyclo-ligasePhosphoribosylglycinamide formyltransferase

Papers overview

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2016
2016
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter…
Targeted antifolates with heteroatom replacements of the carbon vicinal to the phenyl ring in 1 by N (4), O (8), or S (9), or… 
Highly Cited
2012
Highly Cited
2012
Glycyl-tRNA synthetase specifically binds to the poliovirus IRES to activate translation initiation
Adaptation to the host cell environment to efficiently take-over the host cell's machinery is crucial in particular for small RNA… 
Highly Cited
2004
Highly Cited
2004
Limited benefit of antiretroviral resistance testing in treatment-experienced patients: a meta-analysis
Objective: To estimate the effectiveness of resistance assessments based on viral sequencing (genotypic antiretroviral resistance… 
Highly Cited
2004
Highly Cited
2004
AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase
SummaryThe glycinamide ribonucleotide formyltransferase (GARFT) inhibitor, 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5… 
2004
2004
Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol
SummaryLometrexol, a tight-binding antifolate inhibitor of the purine de novo enzyme glycinamide ribonucleotide formyltransferase… 
2003
2003
A Defect in the p53 Response Pathway Induced by de Novo Purine Synthesis Inhibition*
p53 is believed to sense cellular ribonucleotide depletion in the absence of DNA strand breaks and to respond by imposition of a… 
1997
1997
Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase.
The binding of the prototypical folate inhibitor of de novo purine synthesis, 5,10-dideazatetrahydrofolate (DDATHF), and its… 
Highly Cited
1994
Highly Cited
1994
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.
Classical antifolate analogues containing a novel furo[2,3-d]pyrimidine ring system which include N-[4-[N-[(2,4-diaminofuro[2,3-d… 
Highly Cited
1986
Highly Cited
1986
Multiple purine pathway enzyme activities are encoded at a single genetic locus in Drosophila.
The Drosophila melanogaster Gart locus, known from previous work to encode the enzyme activity phosphoribosylglycinamide… 
Highly Cited
1985
Highly Cited
1985
A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine…
Three activities on the pathway of purine biosynthesis de novo in chicken liver, namely, glycinamide ribonucleotide synthetase… 
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