T. Trikalinos

Publications422
h-index59
Citations15,824
Highly Influential Citations646
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Recommendations for Conduct, Methodological Practices, and Reporting of Cost-effectiveness Analyses: Second Panel on Cost-Effectiveness in Health and Medicine.
IMPORTANCE Since publication of the report by the Panel on Cost-Effectiveness in Health and Medicine in 1996, researchers have advanced the methods of cost-effectiveness analysis, and policy makers… Expand
  • 771
  • 61
An exploratory test for an excess of significant findings
Background The published clinical research literature may be distorted by the pursuit of statistically significant results. Purpose We aimed to develop a test to explore biases stemming from the… Expand
  • 365
  • 39
Closing the Gap between Methodologists and End-Users: R as a Computational Back-End
The R environment provides a natural platform for developing new statistical methods due to the mathematical expressiveness of the language, the large number of existing libraries, and the active… Expand
  • 441
  • 38
Differential Effects of NOD2 Variants on Crohn's Disease Risk and Phenotype in Diverse Populations: A Metaanalysis
OBJECTIVES:Three variants of the CARD15/NOD2 gene (SNP8, SNP12, and SNP13) have been associated with Crohn's disease (CD). We assessed the impact of NOD2 variants on the CD risk across diverse… Expand
  • 453
  • 32
Replication validity of genetic association studies
The rapid growth of human genetics creates countless opportunities for studies of disease association. Given the number of potentially identifiable genetic markers and the multitude of clinical… Expand
  • 1,839
  • 27
Vitamin D and calcium: a systematic review of health outcomes.
BACKGROUND Since the 1997 Dietary Reference Intake (DRI) values for vitamin D and calcium were established new data have become available on their relationship, both individually and combined, to a… Expand
  • 357
  • 24
Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations.
The authors evaluated whether statistically significant violations of Hardy-Weinberg equilibrium (HWE) or the magnitude of deviations from HWE may contribute to the problem of replicating postulated… Expand
  • 267
  • 22
Semi-automated screening of biomedical citations for systematic reviews
BackgroundSystematic reviews address a specific clinical question by unbiasedly assessing and analyzing the pertinent literature. Citation screening is a time-consuming and critical step in… Expand
  • 198
  • 20
A summary of the Agency for Healthcare Research and Quality's evidence report on breastfeeding in developed countries.
OBJECTIVES This article summarizes the Agency for Healthcare Research and Quality's evidence report on the effects of breastfeeding on term infant and maternal health outcomes in developed countries.… Expand
  • 388
  • 19
Genetic associations in large versus small studies: an empirical assessment
BACKGROUND Advances in human genetics could help us to assess prognosis on an individual basis and to optimise the management of complex diseases. However, different studies on the same genetic… Expand
  • 588
  • 16