Share This Author
Recommendations for Conduct, Methodological Practices, and Reporting of Cost-effectiveness Analyses: Second Panel on Cost-Effectiveness in Health and Medicine.
The Second Panel on Cost-Effectiveness in Health and Medicine reviewed the current status of the field of cost-effectiveness analysis and developed a new set of recommendations, including the recommendation to perform analyses from 2 reference case perspectives and to provide an impact inventory to clarify included consequences.
Breastfeeding and maternal and infant health outcomes in developed countries.
A history of breastfeeding was associated with a reduced risk of many diseases in infants and mothers from developed countries and cluster randomized controlled studies on the effectiveness of various breastfeeding promotion interventions will provide further opportunity to investigate any disparity in health outcomes as a result of the intervention.
Closing the Gap between Methodologists and End-Users: R as a Computational Back-End
- Byron C. Wallace, I. Dahabreh, T. Trikalinos, J. Lau, Paul Trow, C. Schmid
- Computer Science
- 30 June 2012
This paper presents open-source meta-analysis software that uses R as the underlying statistical engine, and Python for the GUI, and a framework that allows methodologists to implement new methods in R that are then automatically integrated into the GUI for use by end-users, so long as the programmer conforms to the interface.
Differential Effects of NOD2 Variants on Crohn's Disease Risk and Phenotype in Diverse Populations: A Metaanalysis
- M. Economou, T. Trikalinos, Konstantinos T Loizou, E. Tsianos, J. Ioannidis
- MedicineThe American Journal of Gastroenterology
- 1 December 2004
SNP8, SNP12, and SNP13 have differential effects on CD risk, with SNP13 having the strongest genetic effect.
An exploratory test for an excess of significant findings
A test to explore biases stemming from the pursuit of nominal statistical significance was developed and demonstrated a clear or possible excess of significant studies in 6 of 8 large meta-analyses and in the wide domain of neuroleptic treatments.
Replication validity of genetic association studies
- J. Ioannidis, E. Ntzani, T. Trikalinos, D. Contopoulos-Ioannidis
- Biology, PsychologyNature Genetics
- 1 November 2001
It is concluded that a systematic meta-analytic approach may assist in estimating population-wide effects of genetic risk factors in human disease.
Systematic Review: Vitamin D and Cardiometabolic Outcomes
The association between vitamin D status and cardiometabolic outcomes is uncertain and trials showed no clinically significant effect of vitamin D supplementation at the dosages given.
Vitamin D and calcium: a systematic review of health outcomes.
It was difficult to draw firm conclusions on the basis of the available literature concerning the association of either serum 25(OH)D concentration or calcium intake, or the combination of both nutrients on the different health outcomes.
Semi-automated screening of biomedical citations for systematic reviews
- Byron C. Wallace, T. Trikalinos, J. Lau, C. Brodley, C. Schmid
- Computer ScienceBMC Bioinformatics
- 26 January 2010
A semi-automated citation screening algorithm for systematic reviews has the potential to substantially reduce the number of citations reviewers have to manually screen, without compromising the quality and comprehensiveness of the review.
Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations.
- T. Trikalinos, G. Salanti, M. Khoury, J. Ioannidis
- BiologyAmerican journal of epidemiology
- 15 February 2006
Gene-disease association studies and meta-analyses thereof should routinely scrutinize the potential impact of HWE violations as well as nonsignificant deviations from the exact frequencies expected under HWE.