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GAB2 gene

Known as: Grb2-associated binder 2, KIAA0571, GRB2 associated binding protein 2 
This gene plays a role in signal transduction and regulates T-cell proliferation. It is also involved in bone homeostasis and mediates the… 
National Institutes of Health

Related topics

Related topics

3 relations
GAB2 protein, humanSignal Transductionprotein protein interaction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
GAB2 rs2373115 variant contributes to Alzheimer's disease risk specifically in European population
2017
2017
MicroRNA-302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma.
Glioma is the most frequent and aggressive primary tumor of the brain in humans. Over the last few decades, significant progress… 
2016
2016
MiR125a‐5p acting as a novel Gab2 suppressor inhibits invasion of glioma
Poor prognosis of glioma is due to the characteristics of high invasiveness. Recently, it was demonstrated that Gab2 was over… 
2015
2015
Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition
Identification of genomic alterations defining ovarian carcinoma subtypes may aid the stratification of patients to receive… 
2011
2011
Common variant in GAB2 is associated with late-onset Alzheimer's disease in Han Chinese.
2009
2009
GAB2 gene does not modify the risk of Alzheimer’s disease in Spanish APOE 4 carriers
ObjectivesThe genetic basis of Alzheimer’s disease (AD) is being analyzed in multiple whole genome association studies (WGAS… 
2006
2006
Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.
Scaffolding adapter Grb2-associated binder 2 (Gab2) is a key component of FcepsilonRI signaling in mast cells, required for the… 
2001
2001
Gu, H. et al. Essential role for Gab2 in the allergic response. Nature 412, 186-190
Highly Cited
2000
Highly Cited
2000
The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines.
Interleukin (IL)-2, a critical cytokine with indispensable functions in regulating lymphoid homeostasis, induces the activation… 
2000
2000
Epidermal Growth Factor-induced Phosphatidylinositol 3-Kinase Activation and DNA Synthesis
In previous work we showed that the phosphatidylinositol 3-kinase (PI3-kinase), not the mitogen-activated protein kinase, pathway… 
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