GAB2 protein, human

Known as: GAB2 Protein, GRB2-associated binding protein 2, human, GRB2-Associated-Binding Protein 2 
GRB2-Associated Binding Protein 2 (GAB2), encoded by the human GAB2 gene, is the principal activator of phosphatidylinositol-3 kinase in response to… (More)
National Institutes of Health

Papers overview

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2009
2009
PURPOSE Gain-of-function mutations in BRAF, NRAS, or KIT are associated with distinct melanoma subtypes with KIT mutations and/or… (More)
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2009
2009
Metastatic melanoma is a disease with a poor prognosis that currently lacks effective treatments. Critical biological features of… (More)
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2007
2007
Gab2 is an important adapter molecule for cytokine signaling. Despite its major role in signaling by receptors associated with… (More)
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Highly Cited
2006
Highly Cited
2006
The scaffolding adapter GAB2 maps to a region (11q13-14) commonly amplified in human breast cancer, and is overexpressed in… (More)
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Highly Cited
2006
Highly Cited
2006
Excessive bone loss in arthritic diseases is mostly due to abnormal activation of the immune system leading to stimulation of… (More)
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Highly Cited
2006
Highly Cited
2006
The docking protein Gab2 is a proto-oncogene product that is overexpressed in primary breast cancers. To determine the functional… (More)
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Highly Cited
2002
Highly Cited
2002
Mast cells are thought to participate in a variety of immune responses, such as parasite resistance and the allergic reaction… (More)
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Highly Cited
2002
Highly Cited
2002
Hepatitis C virus (HCV) sets up a persistent infection in patients that likely involves a complex virus-host interaction. We… (More)
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Highly Cited
2001
Highly Cited
2001
Dos/Gab family scaffolding adapters (Dos, Gab1, Gab2) bind several signal relay molecules, including the protein-tyrosine… (More)
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Highly Cited
1990
Highly Cited
1990
Antiphosphotyrosine immunoblots were used to characterize tyrosine phosphorylated proteins after stimulation of the human TCR… (More)
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