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Deeper mechanistic understanding of non-small cell lung cancer (NSCLC), a leading cause of total cancer-related deaths, may facilitate the establishment of more effective therapeutic strategies. In this study, pituitary tumor transforming gene (PTTG1) expression was associated with lymph node and distant metastasis in patients with NSCLC and was correlated(More)
Circulating tumor cells (CTCs), which have stem cell-like characteristics, might play a crucial role in cancer metastasis. CD44 has been identified as gastric cancer (GC) stem cell (CSC) marker. Here, the prognostic significance of CD44-positive CTCs in GC patients was investigated. CTCs were detected in 27 of 45 GC patients. The presence of CTCs was(More)
S100A8/A9 proteins are members of EF-hand calcium-binding proteins secreted by neutrophils and activated monocytes. S100A8/A9 has cell growth-promoting activity at low concentrations by binding to the receptor for advanced glycation end products (RAGE). In this study, we report for the first time that S100A8/A9 promoted the invasion of breast cancer cells(More)
An intensified biofilm-electrode reactor (IBER) was developed to treat nitrate-contaminated drinking water. Different running conditions were conducted to investigate the behavior of autotrophic denitrification (AD) and heterotrophic denitrification (HD) in the IBER. In AD process, the nitrate nitrogen coulomb-reduction rate was used to evaluate the(More)
An up-flow anaerobic sludge blanket reactor-microbial fuel cell-biological aerated filter (UASB-MFC-BAF) system was developed for simultaneous bioelectricity generation and molasses wastewater treatment in this study. The maximum power density of 1410.2 mW/m(2) was obtained with a current density of 4947.9 mA/m(2) when the high strength molasses wastewater(More)
Biochemical effects of tetrabromobisphenol A (TBBPA) on the earthworm Eisenia fetida, including superoxide dismutase, catalase, glutathione-S-transferase, reduced glutathione, oxidized glutathione, GSH/GSSG ratio and malondialdehyde (MDA) level, were measured to assess ecological toxicity of TBBPA. With OECD standard filter-paper contact test method,(More)
Oxidative and immune attacks from the environment or microglia have been implicated in the loss of dopaminergic neurons of Parkinson's disease. The role of IgG which is an important immunologic molecule in the process of Parkinson's disease has been unclear. Evidence suggests that IgG can be produced by neurons in addition to its traditionally recognized(More)
Chemokine (C-C motif) ligand 18 (CCL18), which is derived from tumour-associated macrophages (TAMs), plays a critical role in promoting breast cancer metastasis via its receptor, PYK2 N-terminal domain interacting receptor 1 (Nir1). However, the molecular mechanism by which Nir1 promotes breast cancer metastasis by binding to CCL18 remains elusive. In this(More)
Malignant gliomas have a tendency to invade diffusely into surrounding healthy brain tissues, thereby precluding their successful surgical removal. The serine/threonine kinase Akt2 is well known as an important regulator of cell survival and growth. In this study, we show that siRNA-mediated depletion of Akt2 inhibited migration and invasion of glioma(More)
Poor prognosis of malignant gliomas is primarily attributed to their highly invasive nature. Despite the identification of new biomarkers and molecular targets for the improvement of the diagnosis, prognosis and treatment of glioma, the overall prognosis of the disease remains poor. This study is the first to show the significant upregulation of ARK5(More)