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G(M2) Activator Protein

Known as: G(M2) Activator Protein [Chemical/Ingredient], Hexosaminidase Activator, Activator Protein, GM2 
An essential cofactor for the degradation of G(M2)GANGLIOSIDE by lysosomal BETA-N-ACETYLHEXOSAMINIDASES. Genetic mutations resulting in loss of G(M2… 
National Institutes of Health

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In BloodProcess of secretionTay-Sachs Disease, AB Variantagonists

Papers overview

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2018
2018
Synthetic Studies of GM2 Activator Protein (GM2AP) for Potential Therapeutic Agents of Lysosomal Storage Diseases
2016
2016
Combined replacement effects of human modified β-hexosaminidase B and GM2 activator protein on GM2 gangliosidoses fibroblasts
2009
2009
Sequential proteolysis and high-field FTICR MS to determine disulfide connectivity and 4-maleimide TEMPO spin-label location in L126C GM2 activator protein.
The GM2 activator protein (GM2AP) is an 18 kDa nonenzymatic accessory protein involved in the degradation of neuronal… 
Highly Cited
2002
Highly Cited
2002
Kidney Sulfatides in Mouse Models of Inherited Glycosphingolipid Disorders
Sulfatides show structural, and possibly physiological similarities to gangliosides. Kidney dysfunction might be correlated with… 
2002
2002
Study of Interaction of GM2 Activator Protein with GM2 Using Circular Dichroism and Fluorescence Spectroscopy
GM2 activator protein (GM2AP) is a cofactor for stimulating the enzymatic hydrolysis of the glycolipid GM2 by β-hexosaminidase A… 
1998
1998
LOCATION OF GANGLIOSIDE GM2 ACTIVATOR PROTEIN GENE EXPRESSION IN SHEEP
1. The present study was aimed at characterizing and establishing the site of production of a ‘novel’ protein isolated in 1988… 
1997
1997
Biosynthesis, Processing, and Intracellular Transport of GM2 Activator Protein in Human Epidermal Keratinocytes
The processing, intracellular transport, and endocytosis of the GM2 activator protein (GM2AP), an essential cofactor of… 
1994
1994
The mouse gene encoding the GM2 activator protein (Gm2a): cDNA sequence, expression, and chromosome mapping.
The GM2 activator protein forms a substrate-complex with GM2 ganglioside, which enables degradation of the ganglioside by beta… 
1993
1993
Refined mapping of the GM2 activator protein (GM2A) locus to 5q31.3-q33.1, distal to the spinal muscular atrophy locus.
The GM2 activator locus (GM2A) had previously been considered as a candidate gene for some forms of spinal muscular atrophy (SMA… 
1993
1993
Regional localization of the gene coding for the GM2 activator protein (GME2A) to chromosome 5q32‐33 and confirmation of the assignment of GM3AP to chromosome 3
The gene coding for the GM2 activator protein (GM2A) was previously mapped by us to chromosome 5 by an ELISA‐based technique… 
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