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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
TLDR
It is established that S1P1 is essential for lymphocyte recirculation and that it regulates egress from both thymus and peripheral lymphoid organs.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.
TLDR
The data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development.
Mouse models of Tay–Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism
TLDR
The Tay–Sachs and Sandhoff diseases are clinically similar neurodegenerative disorders and through disruption of the Hexa and Hexb genes in embryonic stem cells, mouse models corresponding to each disease are established.
Lysosomal Glycosphingolipid Recognition by NKT Cells
TLDR
It is suggested that expression of iGb3 in peripheral tissues may be involved in controlling NKT cell responses to infections and malignancy and in autoimmunity.
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone
TLDR
It is reported that FTY720, a drug that targets sphingosine 1-phosphate (S1P) receptors, induced marginal zone B cell migration into follicles, and using gene-targeted mice, it is shown that S1P1 but not S1p3 was required for localization in the marginal zone.
Essential Role for Sphingosine Kinases in Neural and Vascular Development
TLDR
It is shown that S1P signaling is critical for neural and vascular development and joins a growing list of signaling molecules, such as vascular endothelial growth factor, which regulate the functionally intertwined pathways of angiogenesis and neurogenesis.
Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720*
TLDR
The results with these Sphk1 null mice reveal that some key physiologic processes that require S1P receptor signaling, such as vascular development and proper lymphocyte distribution, can occur in the absence of SPHK1.
The alliance of sphingosine-1-phosphate and its receptors in immunity
TLDR
Findings indicate that the alliance between S1P and its receptors has a fundamental role in immunity, and the discovery of regulatory mechanisms in S1p-mediated immune-cell trafficking and new advances in understanding the mechanism by which S 1P affects immune- cell function indicate that this alliance is important for immunity.
Mice Expressing Only Monosialoganglioside GM3 Exhibit Lethal Audiogenic Seizures*
TLDR
It is demonstrated unequivocally that gangliosides play an essential role in the proper functioning of the central nervous system (CNS) and that GD3S−/− mice, even with an absence of b-series ganglioides, appear to undergo normal development and have a normal life span.
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