Focal Adhesions

Known as: Plaques, Adhesion, Adherens Junctions, Cell-Matrix, Cell to matrix adherens junction 
An anchoring junction of the cell to a non-cellular substrate. It is composed of a specialized area of the plasma membrane where bundles of the ACTIN… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1949-2018
020040060019492017

Papers overview

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Review
2017
Review
2017
Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves an important scaffolding role at focal… (More)
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Highly Cited
2010
Highly Cited
2010
Cell adhesions to the extracellular matrix (ECM) are necessary for morphogenesis, immunity and wound healing. Focal adhesions are… (More)
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Highly Cited
2010
Highly Cited
2010
Mechanical forces are central to developmental, physiological and pathological processes. However, limited understanding of force… (More)
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Highly Cited
2001
Highly Cited
2001
Mechanical forces play a major role in the regulation of cell adhesion and cytoskeletal organization. In order to explore the… (More)
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Highly Cited
1998
Highly Cited
1998
The tumor suppressor PTEN is a phosphatase with sequence similarity to the cytoskeletal protein tensin. Here the cellular roles… (More)
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Highly Cited
1997
Highly Cited
1997
The small guanosine triphosphatase (GTPase) Rho is implicated in the formation of stress fibers and focal adhesions in… (More)
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Highly Cited
1996
Highly Cited
1996
Activated rhoA, a ras-related GTP-binding protein, stimulates the appearance of stress fibers, focal adhesions, and tyrosine… (More)
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Highly Cited
1995
Highly Cited
1995
Rho and rac, two members of the ras-related superfamily of small GTPases, regulate the polymerization of actin to produce stress… (More)
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Highly Cited
1995
Highly Cited
1995
THE intracellular protein tyrosine kinase FAK (focal adhesion kinase) was originally identified by its high level of tyrosine… (More)
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Highly Cited
1992
Highly Cited
1992
Actin stress fibers are one of the major cytoskeletal structures in fibroblasts and are linked to the plasma membrane at focal… (More)
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