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Fluorescent Imaging Ligand OTL38

Known as: OTL38 
A fluorescent imaging agent composed of a folate receptor-alpha (FRa)-targeting ligand conjugated to a fluorescent near infrared (NIR) dye, that can… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Intraoperative near-infrared imaging with receptor-specific versus passive delivery of fluorescent agents in pituitary adenomas.
OBJECTIVEIntraoperative molecular imaging with tumor-targeted fluorescent dyes can enhance resection rates. In contrast to… 
2019
2019
Folate Receptor Near-Infrared Optical Imaging Provides Sensitive and Specific Intraoperative Visualization of Nonfunctional Pituitary Adenomas.
BACKGROUND Surgical resection is the primary treatment for nonfunctional (NF) pituitary adenomas, but gross-total resection is… 
Review
2018
Review
2018
Intraoperative fluorescence imaging in thoracic surgery
Intraoperative fluorescence imaging (IFI) can improve real‐time identification of cancer cells during an operation. Phase I… 
Highly Cited
2018
Highly Cited
2018
Evaluation of Novel Tumor-Targeted Near-Infrared Probe for Fluorescence-Guided Surgery of Cancer.
Because the most reliable therapy for cancer involves quantitative resection of all diseased tissue, considerable effort has been… 
Review
2018
Review
2018
Use of optical fluorescence agents during surgery for pituitary adenomas: current state of the field
IntroductionDifferentiation of normal pituitary from abnormal tumor tissue remains a surgical challenge despite improvements in… 
Review
2017
Review
2017
Identification of a Folate Receptor-Targeted Near-Infrared Molecular Contrast Agent to Localize Pulmonary Adenocarcinomas.
Highly Cited
2017
Highly Cited
2017
Folate receptor overexpression can be visualized in real time during pituitary adenoma endoscopic transsphenoidal surgery with near-infrared imaging.
OBJECTIVE Pituitary adenomas account for approximately 10% of intracranial tumors and have an estimated prevalence of 15%-20% in… 
2016
2016
Novel Use of Folate-Targeted Intraoperative Fluorescence, OTL38, in Robot-Assisted Laparoscopic Partial Nephrectomy: Report of the First Three Cases
Abstract Partial nephrectomy is now the preferred surgical option for small renal tumors because it allows nephron preservation… 
2016
2016
Novel Tumor-Speci fi c Agent for Intraoperative Near-Infrared Fluorescence Imaging : A Translational Study in Healthy Volunteers and Patients with Ovarian Cancer
Purpose: Completeness of cytoreductive surgery is a key prognostic factor for survival in patients with ovarian cancer. The… 
Highly Cited
2015
Highly Cited
2015
Comparison of Folate Receptor Targeted Optical Contrast Agents for Intraoperative Molecular Imaging
Background. Intraoperative imaging can identify cancer cells in order to improve resection; thus fluorescent contrast agents have… 
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