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Myeloid derived suppressor cells
The goal of achieving measurable response with cancer immunotherapy requires counteracting the immunosuppressive characteristics of tumors. One of the mechanisms that tumors utilize to escapeExpand
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Evolving options in the management of esophageal perforation.
Esophageal perforation remains a devastating event that is difficult to diagnose and manage. The majority of injuries are iatrogenic and the increasing use of endoscopic procedures can be expected toExpand
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Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils
The role of myeloid cells in supporting cancer growth is well established. Most work has focused on myeloid-derived suppressor cells (MDSC) that accumulate in tumor-bearing animals, butExpand
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Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer.
Infiltrating inflammatory cells are highly prevalent within the tumor microenvironment and mediate many processes associated with tumor progression; however, the contribution of specific populationsExpand
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Prognostic Implications of Cell Cycle, Apoptosis, and Angiogenesis Biomarkers in Non–Small Cell Lung Cancer: A Review
Lung cancer is the leading cause of cancer death in the U.S. with survival restricted to a subset of those patients able to undergo surgical resection. However, even with surgery, recurrence ratesExpand
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Current management of esophageal leiomyoma.
Morgagni first described leiomyoma as a distinct gastrointestinal neoplasm in 1761, but Munro in 1797 was the first to report a localized intramural leiomyoma of the esophagus. Much of what is knownExpand
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Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer.
Based on studies in mouse tumor models, granulocytes appear to play a tumor-promoting role. However, there are limited data about the phenotype and function of tumor-associated neutrophils (TANs) inExpand
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Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity
Metastasis via the lymphatics is a major risk factor in squamous cell carcinoma of the oral cavity (OSCC). We sought to determine whether the presence of metastasis in the regional lymph node couldExpand
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Gene expression profiling of the early pulmonary response to hyperoxia in mice.
To identify molecular events occurring during the early response to hyperoxia, we measured changes over time in total lung gene expression in C57BL/6 mice during prolonged exposure to > 95% O2.Expand
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Folate Receptor Alpha Expression in Lung Cancer: Diagnostic and Prognostic Significance
With the advent of targeted therapies directed towards folate receptor alpha, with several such agents in late stage clinical development, the sensitive and robust detection of folate receptor alphaExpand
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