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A genetic model for colorectal tumorigenesis
Tumorigenesis has long been thought to be a multistep process (Foulds, 1958); however, only recently has it become possible to identify the molecular events that underlie the initiation and… Expand
WAF1, a potential mediator of p53 tumor suppression
- W. El-Deiry, T. Tokino, V. Velculescu, D. B. Levy, B. Vogelstein
- Medicine, Biology
- 19 November 1993
The ability of p53 to activate transcription from specific sequences suggests that genes induced by p53 may mediate its biological role as a tumor suppressor. Using a subtractive hybridization… Expand
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
A technique for conveniently radiolabeling DNA restriction endonuclease fragments to high specific activity is described. DNA fragments are purified from agarose gels directly by ethanol… Expand
Lessons from Hereditary Colorectal Cancer
The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and for their critical reading of the manuscript and to F. Giardiello and S. Hamilton for… Expand
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
There are currently few therapeutic options for patients with pancreatic cancer, and new insights into the pathogenesis of this lethal disease are urgently needed. Toward this end, we performed a… Expand
Identification of c-MYC as a target of the APC pathway.
The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of APC cause aberrant accumulation of beta-catenin, which then binds T… Expand
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important for neoplasia, including cell proliferation, adhesion, survival, and motility ([ 1 ]–[ 3 ]).… Expand
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
The adenomatous polyposis coli (APC) tumor suppressor protein binds to β-catenin, a protein recently shown to interact with Tcf and Lef transcription factors. The gene encoding hTcf-4, a Tcf family… Expand
Surfing the p53 network
The p53 tumour-suppressor gene integrates numerous signals that control cell life and death. As when a highly connected node in the Internet breaks down, the disruption of p53 has severe consequences.
Genetic instabilities in human cancers
Whether and how human tumours are genetically unstable has been debated for decades. There is now evidence that most cancers may indeed be genetically unstable, but that the instability exists at two… Expand