Fleroxacin

Known as: Fleroxacin [Chemical/Ingredient], Fleroxacinum, 6,8-Difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid 
A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1987-2017
020406019872017

Papers overview

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Highly Cited
2010
Highly Cited
2010
The residue levels of selected fluoroquinolones, sulfonamides and tetracyclines in 143 animal dung samples collected in 2007 from… (More)
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2004
2004
BACKGROUND Oral combination therapy with fluoroquinolones plus rifampicin is a promising alternative to standard parenteral… (More)
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2001
2001
Quinolone therapy can be associated with tendon disorders (tendinitis, ruptures), but little is known about possible… (More)
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1997
1997
The effect of fleroxacin on gentamicin-induced nephrotoxicity was evaluated with female Sprague-Dawley rats. Animals were… (More)
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1994
1994
Scanning confocal laser microscopy (SCLM) and fluorescent molecular probes were used to evaluate the effect of the… (More)
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1989
1989
A sensitive and convenient method for quinolone determination has been developed, based on the natural fluorescence of the… (More)
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1989
1989
Spontaneous fleroxacin-resistant mutants of Escherichia coli K-12 were isolated at a frequency of 10(-10) to 10(-11) mutants per… (More)
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1989
1989
New fluoroquinolones have generally been well tolerated. In a double-blind evaluation of oral fleroxacin, using 400, 600, or 800… (More)
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1988
1988
The effects of fleroxacin and other new 4-quinolones on cellular functions and topoisomerase II of HeLa cells were investigated… (More)
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1988
1988
The tolerance and pharmacokinetics of fleroxacin were studied in healthy male adult volunteers. The peak serum concentrations of… (More)
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