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Fleroxacin

Known as: Fleroxacin [Chemical/Ingredient], Fleroxacinum, 6,8-Difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid 
A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
National Institutes of Health

Related topics

Related topics

16 relations

Narrower (5)

AM-833Megalone (TN)QuinodisRo 23-6240
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Broader (2)

Anti-Infective AgentsTopoisomerase II Inhibitors
Fleroxacin:Susc:Pt:Isolate:OrdQnFleroxacin:Susc:Pt:Isolate:OrdQn:MICIn Bloodagonists
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Occurrence and fate of quinolone and fluoroquinolone antibiotics in a municipal sewage treatment plant.
This study developed a method for analysis of nineteen quinolone and fluoroquinolone antibiotics (FQs) in sludge samples, and… Expand
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Highly Cited
2011
Highly Cited
2011
Occurrence, distribution and seasonal variation of antibiotics in the Huangpu River, Shanghai, China.
Water samples were collected from 19 sampling sites along the Huangpu River in June and December 2009. The occurrence… Expand
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Highly Cited
2010
Highly Cited
2010
Residues of veterinary antibiotics in manures from feedlot livestock in eight provinces of China.
The residue levels of selected fluoroquinolones, sulfonamides and tetracyclines in 143 animal dung samples collected in 2007 from… Expand
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Highly Cited
2004
Highly Cited
2004
A randomized clinical trial to compare fleroxacin-rifampicin with flucloxacillin or vancomycin for the treatment of staphylococcal infection.
BACKGROUND Oral combination therapy with fluoroquinolones plus rifampicin is a promising alternative to standard parenteral… Expand
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2001
2001
Ultrastructure of Achilles tendon from rats after treatment with fleroxacin
Abstract. Quinolone therapy can be associated with tendon disorders (tendinitis, ruptures), but little is known about possible… Expand
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Review
1999
Review
1999
Toxicity of Quinolones
Reactions of the gastrointestinal tract, the CNS and the skin are the most often observed adverse effects during therapy with… Expand
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1997
1997
The cytotoxic effect of fleroxacin and ciprofloxacin on transitional cell carcinoma in vitro.
BACKGROUND There have been few reports concerning the cytotoxic effects of fluoroquinolone antibiotics on transitional cell… Expand
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Review
1995
Review
1995
Drugs of choice for the treatment of uncomplicated gonococcal infections.
Resistance of Neisseria gonorrhoeae to antimicrobial agents continues to spread and intensify. Choosing an antimicrobial regimen… Expand
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1994
1994
Evaluation of Fleroxacin Activity against Established Pseudomonas fluorescens Biofilms.
Scanning confocal laser microscopy (SCLM) and fluorescent molecular probes were used to evaluate the effect of the… Expand
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Highly Cited
1988
Highly Cited
1988
Routes of quinolone permeation in Escherichia coli.
The uptake of quinolone antibiotics by Escherichia coli was investigated by using fleroxacin (RO 23-6240, AM 833) as a prototype… Expand
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