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Fleroxacin

Known as: Fleroxacin [Chemical/Ingredient], Fleroxacinum, 6,8-Difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid 
A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
National Institutes of Health

Related topics

Related topics

16 relations

Narrower (5)

AM-833Megalone (TN)QuinodisRo 23-6240

Broader (2)

Anti-Infective AgentsTopoisomerase II Inhibitors
Fleroxacin:Susc:Pt:Isolate:OrdQnFleroxacin:Susc:Pt:Isolate:OrdQn:MICIn Bloodagonists

Papers overview

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2005
2005
Spectrofluorimetric study of the charge-transfer complexation of certain fluoroquinolones with 7,7,8,8-tetracyanoquinodimethane.
2003
2003
Fluorescence spectroscopy determination of fluoroquinolones by charge-transfer reaction.
1999
1999
Comparative studies of modulatory effect to the function of rat peritoneal neutrophils treated with new quinolones.
Highly Cited
1998
Highly Cited
1998
Photocleavage of DNA by the fluoroquinolone antibacterials.
Highly Cited
1997
Highly Cited
1997
Photogeneration of Fluoride by the Fluoroquinolone Antimicrobial Agents Lomefloxacin and Fleroxacin
The photolysis (> 320 nm) of the fluoroquinolone antibacterial agents lomefloxacin and fleroxacin results in the loss of their F3… 
1993
1993
Pharmacokinetics of [18F]fleroxacin in healthy human subjects studied by using positron emission tomography
Positron emission tomography (PET) with [18F]fleroxacin was used to study the pharmacokinetics of fleroxacin, a new broad… 
Review
1992
Review
1992
Fleroxacin Clinical Pharmacokinetics
SummaryFleroxacin is a new member of the class of fluoroquinolones. The drug has good activity (i.e. minimum inhibitory… 
1991
1991
Antimicrobial activity evaluations of two new quinolones, PD127391 (CI-960 and AM-1091) and PD131628.
1988
1988
Multicenter in vitro evaluation of lomefloxacin (NY-198, SC-47111), including tests against nearly 7,000 bacterial isolates and preliminary recommendations for susceptibility testing.
1988
1988
Single and multiple dose pharmacokinetics of fleroxacin.
Pharmacokinetics of fleroxacin following single and multiple dosing were studied in healthy male volunteers. The characteristics… 
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