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Fleroxacin

Known as: Fleroxacin [Chemical/Ingredient], Fleroxacinum, 6,8-Difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid 
A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
National Institutes of Health

Related topics

Related topics

16 relations

Narrower (5)

AM-833Megalone (TN)QuinodisRo 23-6240

Broader (2)

Anti-Infective AgentsTopoisomerase II Inhibitors
Fleroxacin:Susc:Pt:Isolate:OrdQnFleroxacin:Susc:Pt:Isolate:OrdQn:MICIn Bloodagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Systematic optimization of an SPE with HPLC-FLD method for fluoroquinolone detection in wastewater.
Highly Cited
2013
Highly Cited
2013
Dispersive liquid-liquid microextraction combined with ultra-high performance liquid chromatography for the simultaneous determination of 25 sulfonamide and quinolone antibiotics in water samples.
Highly Cited
2011
Highly Cited
2011
Occurrence, distribution and seasonal variation of antibiotics in the Huangpu River, Shanghai, China.
Highly Cited
2007
Highly Cited
2007
A flow injection chemiluminescence method for the determination of fluoroquinolone derivative using the reaction of luminol and hydrogen peroxide catalyzed by gold nanoparticles.
Highly Cited
2004
Highly Cited
2004
A randomized clinical trial to compare fleroxacin-rifampicin with flucloxacillin or vancomycin for the treatment of staphylococcal infection.
BACKGROUND Oral combination therapy with fluoroquinolones plus rifampicin is a promising alternative to standard parenteral… 
Review
2002
Review
2002
Ceftriaxone: an update of its use in the management of community-acquired and nosocomial infections.
UNLABELLED Ceftriaxone is a parenteral third-generation cephalosporin with a long elimination half-life which permits once-daily… 
Highly Cited
2000
Highly Cited
2000
The qualitative and quantitative determination of quinolones of first and second generation by capillary electrophoresis.
Highly Cited
2000
Highly Cited
2000
In vitro and in vivo investigations on fluoroquinolones; effects of the P-glycoprotein efflux transporter on brain distribution of sparfloxacin.
Highly Cited
1997
Highly Cited
1997
Fluoroquinolone antibacterials enhance UVA-induced skin tumors.
Highly Cited
1997
Highly Cited
1997
Quinolone antibacterials: a new class of photochemical carcinogens.
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