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Fasidotril

National Institutes of Health

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aladotril

Papers overview

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2016
2016
Neprilysin : Indications , Expectations , and Challenges Neprilisina : indicaciones , expectativas y retos
Neprilysin has become a focus of interest in cardiology, due to the impressive benefits of combining neprilysin inhibition and… 
2008
2008
Synthesis of Fasidotril
2-Hydroxymethyl-3-(3,4-methylenedioxy)phenyl propionic acid (7) prepared by selective reduction from potassium 2-ethoxycarbonyl-3… 
2007
2007
Process improvement on the synthesis of fasidotril
Objective:To improve the synthetic procedure of fasidotril.Method: Fasidotril was synthesized from piperonylacrylic acide through… 
2006
2006
Fasidotril: The First Dual Inhibitor of Neprilysin and ACE
Keywords: Angiotensin converting enzyme; Dual inhibitor; Heart failure; Hypertension; Neprilysin 
Review
2003
Review
2003
Fasidotril Eli Lilly.
Lilly is developing fasidotril, a diester prodrug of the active metabolite fasidotrilat, for the potential treatment of… 
Review
2002
Review
2002
Review: Vasopeptidase inhibitors
Vasopeptidase inhibitors are a new class of drugs that have dual inhibitory effects on two key enzymes involved in the metabolism… 
2000
2000
Antihypertensive effects of fasidotril, a dual inhibitor of neprilysin and angiotensin-converting enzyme, in rats and humans.
The aim of this study was to assess the antihypertensive activity of fasidotril, a dual inhibitor of neprilysin (NEP) and… 
1999
1999
Effect of long-term therapy with fasidotril, a mixed inhibitor of neprilysin and angiotensin-converting enzyme (ACE), on survival of rats after myocardial infarction.
1999
1999
Effect of long-term therapy with fasidotril , a mixed inhibitor of neprilysin and angiotensin-converting enzyme ( ACE ) , on survival of rats after 1 myocardial infarction
Objective: Two hormonal systems with opposite effects are activated in congestive heart failure: the renin–angiotensin system… 
1999
1999
Fasidotril. Aladotril, alatriopril, BP 1137.
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