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Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method.
The aim of the present analysis was to assess the genetic control of CYP3A4 activity in vivo and indicated that further molecular genetic investigations are warranted to identify genetic variants at CYP 3A4 or elsewhere in the genome which contribute to regulation of CYp3A 4 activity. Expand
Novelty seeking and the dopamine D4 receptor gene (DRD4) revisited in Asians: Haplotype characterization and relevance of the 2‐repeat allele
It is suggested that genetic association analyses can benefit by consideration of the shared functional and evolutionary attributes of the DRD4 2R and 7R alleles. Expand
CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine
CYP2D6 seems to be an independent contributor to pituitary pharmacodynamic tissue sensitivity to perphenazine after accounting for DRD2 functional polymorphisms, which provides a basis for further studies on the endogenous substrates of CYP2D 6 and the rational selection of candidate genes for long-term consequences of antipsychotic-induced hyperprolactinemia. Expand
Aripiprazole (Otsuka Pharmaceutical Co).
The mechanism of action of aripiprazole differentiates it from both typical and atypical antipsychotics and hence, may provide important leads for pharmacotherapy of schizophrenia and other psychotic disorders. Expand
All the post-genomic world is a stage: the actors and narrators required for translating pharmacogenomics into public health.
Author for correspondence: Research Group on Complex Collaboration, Faculty of Management, McGill University, 1001 Sherbrooke Street West, Montreal, QC H3A 1G5, Canada and Centre of Genomics andExpand
Frequency of genetic polymorphisms of COX1, GPIIIa and P2Y1 in a Chinese population and association with attenuated response to aspirin.
The presence of the P2Y1 893CC genotype appears to confer an attenuated antiplatelet effect during aspirin treatment in healthy Chinese volunteers, underscore the importance of population-to-population variability in clinical pharmacogenetics research and provide a basis for further long-term studies of aspirin response and P2y1 genetic variation in patients with cardiovascular risk. Expand
Lack of association between serotonin-2A receptor gene (HTR2A) polymorphisms and tardive dyskinesia in schizophrenia
Polymorphisms in HTR2A do not appear to influence the risk for TD, and in tandem multiple candidate genes relevant for the serotonergic system are warranted to dissect the genetic basis of the complex TD phenotype. Expand
Effect of venlafaxine on imipramine metabolism
Findings are consistent with a statistically significant, but clinically modest impact of venlafaxine on CYP2D6-metabolized substrates. Expand
Concentration-Response Relationship for Fluvoxamine Using Remission as an Endpoint: A Receiver Operating Characteristics Curve Analysis in Major Depression
Therapeutic drug monitoring may be useful for rational titration and individualization of fluvoxamine dose and predicting remission in patients with moderate to severe depression, who may presumably display lesser placebo component in pharmacodynamic response. Expand