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FTI 276

Known as: FTI-276 
National Institutes of Health

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2 relations

Broader (1)

Methionine
analogs & derivatives

Papers overview

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2013
2013
Effect of farnesyltransferase inhibition on cardiac remodeling in spontaneously hypertensive rats.
2013
2013
Pharmacological modulation of geranylgeranyltransferase and farnesyltransferase attenuates opioid withdrawal in vivo and in vitro
2011
2011
Akt-mediated signaling is induced by cytokines and cyclic adenosine monophosphate and suppresses hepatocyte inducible nitric oxide synthase expression independent of MAPK P44/42.
2010
2010
Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is an accelerated aging disorder caused by mutations in LMNA leading to expression of… 
2008
2008
Autophagy induced by farnesyltransferase inhibitors in cancer cells
The mechanisms of action of farnesyltransferase inhibitors (FTIs) involve Rheb and the phosphatidylinositide 3-kinase/Akt… 
2003
2003
Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf
Mutations in the Kras2 gene are seen in both human and mouse lung adenocarcinomas. The protein product (p21ras) encoded by the… 
2000
2000
CHEMOPREVENTIVE EFFICACY OF PROMISING FARNESYLTRANSFERASE INHIBITORS
The studies presented were designed to test the efficacy of farnesyltransferase inhibitors (FTIs) as potential chemopreventive… 
1999
1999
Discovery of a series of cyclohexylethylamine-containing protein farnesyltransferase inhibitors exhibiting potent cellular activity.
Synthesis of a library of secondary benzylic amines based on the Sebti-Hamilton type peptidomimetic farnesyltransferase (FTase… 
1999
1999
Cytotoxic Agents Cisplatin , Taxol , and Gemcitabine Geranylgeranyltransferase I : Combination Therapy with the Peptidomimetic Inhibitors of Farnesyltransferase and Antitumor Efficacy of a Novel…
Ras malignant transformation requires posttranslational modification by farnesyltransferase (FTase). Here we report on the design… 
1998
1998
Potent and selective non-cysteine-containing inhibitors of protein farnesyltransferase.
Potent and selective non-thiol-containing inhibitors of protein farnesyltransferase are described. FTI-276 (1) was transformed… 
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