FR900359
National Institutes of Health
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Heterotrimeric G proteins are the core upstream elements that transduce and amplify the cellular signals from G protein–coupled…
Inhibition of constitutively activated, oncogenic G proteins inhibits uveal melanoma tumor growth in mice. Targeting uveal…
The cyclic depsipeptide FR900359 (FR), isolated from the tropical plant Ardisia crenata, is a strong and selective inhibitor of…
The cyclic depsipeptide FR900359 (FR), isolated from the traditional Chinese medicine plant Ardisia crenata, is a potent Gq…
Gαqβγ heterotrimer (Gq), an important mediator in the pathology of airway disease, plays a central role in bronchoconstriction…
G proteins are key mediators of G protein-coupled receptor signalling, which facilitates a plethora of important physiological…
Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors…