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FR 167653

Known as: FR167653 
 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (5)

Anti-Inflammatory Agents, Non-SteroidalGrowth InhibitorsImmunosuppressive AgentsPyrazoles
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Highly Cited
2009
Highly Cited
2009
Activation of p38 Mitogen-activated Protein Kinase in Spinal Microglia Contributes to Incision-induced Mechanical Allodynia
Background:Recent studies have implicated the activation of stress-activated mitogen-activated protein kinase (MAPK) p38 in… Expand
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Highly Cited
2007
Highly Cited
2007
Effect of TNF-α inhibition on urinary albumin excretion in experimental diabetic rats
The objective is to assess the effect of TNF-α inhibition on urinary albumin excretion in experimental diabetic rats. Male Wistar… Expand
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Highly Cited
2006
Highly Cited
2006
Opposing effect of p38 MAP kinase and JNK inhibitors on the development of heart failure in the cardiomyopathic hamster.
OBJECTIVE p38 MAP kinase (p38 MAPK) and c-Jun NH2-terminal kinase (JNK) have been implicated in the pathophysiology of heart… Expand
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Highly Cited
2005
Highly Cited
2005
Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome.
Podocytes play an important role in maintaining normal glomerular function and structure, and podocyte injury leads to… Expand
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Highly Cited
2005
Highly Cited
2005
Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia
&NA; Alterations in the intracellular signal transduction pathway in primary afferents may contribute to pain hypersensitivity… Expand
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Highly Cited
2003
Highly Cited
2003
Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653.
OBJECTIVE FR167653 is a potent inhibitor of p38 mitogen-activated protein kinase (MAPK) and inhibits tumor necrosis factor alpha… Expand
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Highly Cited
2001
Highly Cited
2001
FR167653, a p38 mitogen-activated protein kinase inhibitor, prevents Helicobacter pylori-induced gastritis in Mongolian gerbils.
FR167653 was discovered as a cytokine production inhibitor, but its target molecule has remained unclear. We examined the effect… Expand
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Highly Cited
2000
Highly Cited
2000
Role of p38 Mitogen-Activated Protein Kinase in Neointimal Hyperplasia After Vascular Injury
Abstract—p38 mitogen-activated protein kinase (MAPK) is involved in intracellular signals that regulate a variety of cellular… Expand
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Highly Cited
1999
Highly Cited
1999
Roles of enterobacteria, nitric oxide and neutrophil in pathogenesis of indomethacin-induced small intestinal lesions in rats.
Roles of enterobacteria, nitric oxide (NO) and neutrophil in indomethacin-induced small intestinal lesions were examined in rats… Expand
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Highly Cited
1996
Highly Cited
1996
Effect of FR167653, a cytokine suppressive agent, on endotoxin-induced disseminated intravascular coagulation.
FR167653 (1-[7-(4-fluorophenyl)-1,2,3,4-tetrahydro-8-(4-pyridyl)pyrazolo[5-1-c] [1,2,4]triazin-2-yl]-2-phenylethanedione sulfate… Expand
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