FR 167653

Known as: FR167653 
 
National Institutes of Health

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Broader (5)

Anti-Inflammatory Agents, Non-SteroidalGrowth InhibitorsImmunosuppressive AgentsPyrazoles
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Papers overview

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Highly Cited
2009
Highly Cited
2009
Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia.
BACKGROUND Recent studies have implicated the activation of stress-activated mitogen-activated protein kinase (MAPK) p38 in… (More)
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Highly Cited
2007
Highly Cited
2007
Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model.
BACKGROUND Current evidence indicates that p38 mitogen-activated protein kinase activation in spinal microglia contributes to the… (More)
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2007
2007
Effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats.
The objective is to assess the effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats. Male… (More)
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2007
2007
Glial phosphorylated p38 MAP kinase mediates pain in a rat model of lumbar disc herniation and induces motor dysfunction in a rat model of lumbar spinal canal stenosis.
STUDY DESIGN Immunohistochemical and behavioral study using rat models of lumbar disc herniation and cauda equina syndrome… (More)
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2006
2006
Opposing effect of p38 MAP kinase and JNK inhibitors on the development of heart failure in the cardiomyopathic hamster.
OBJECTIVE p38 MAP kinase (p38 MAPK) and c-Jun NH2-terminal kinase (JNK) have been implicated in the pathophysiology of heart… (More)
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2005
2005
Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia
Alterations in the intracellular signal transduction pathway in primary afferents may contribute to pain hypersensitivity. We… (More)
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Highly Cited
2003
Highly Cited
2003
Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653.
OBJECTIVE FR167653 is a potent inhibitor of p38 mitogen-activated protein kinase (MAPK) and inhibits tumor necrosis factor alpha… (More)
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2002
2002
P38 mitogen-activated protein kinase inhibition attenuates ischemia-reperfusion injury of the rat liver.
BACKGROUND Several studies have implicated the mitogen-activated protein kinase (MAPK) signal pathway in non-hepatic organ… (More)
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2002
2002
Administration of FR167653, a new anti-inflammatory compound, prevents renal ischaemia/reperfusion injury in mice.
BACKGROUND Various types of chemokines/cytokines play important roles in ischaemia/reperfusion injury in kidneys. However, the… (More)
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2000
2000
Role of p38 mitogen-activated protein kinase in neointimal hyperplasia after vascular injury.
p38 mitogen-activated protein kinase (MAPK) is involved in intracellular signals that regulate a variety of cellular responses… (More)
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