FOXO1 wt Allele

Known as: FKHR, FKH1, FOXO1A Gene 
Human FOXO1 wild-type allele is located in the vicinity of 13q14.1 and is approximately 111 kb in length. This allele, which encodes forkhead box… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
The identification of molecular differences in the endometrium of women with endometriosis is an important step toward… (More)
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Highly Cited
2005
Highly Cited
2005
Forkhead transcription factors FOXO1 (FKHR), FOXO3a (FKHRL1), and FOXO4 (AFX) play a pivotal role in tumor suppression by… (More)
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Highly Cited
2003
Highly Cited
2003
Hepatic gluconeogenesis is absolutely required for survival during prolonged fasting or starvation, but is inappropriately… (More)
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Highly Cited
2003
Highly Cited
2003
Forkhead transcription factor FKHR (Foxo1) is a key regulator of glucose homeostasis, cell-cycle progression, and apoptosis. It… (More)
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Highly Cited
2002
Highly Cited
2002
Mutations in PTEN occur in 60-80% of prostate cancers and lead to a constitutive activation of the phosphatidylinositol 3-kinase… (More)
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Highly Cited
2000
Highly Cited
2000
PTEN acts as a tumor suppressor, at least in part, by antagonizing phosphoinositide 3-kinase (PI3K)/Akt signaling. Here we show… (More)
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Highly Cited
1999
Highly Cited
1999
Protein kinase B lies "downstream" of phosphatidylinositide (PtdIns) 3-kinase and is thought to mediate many of the intracellular… (More)
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Highly Cited
1999
Highly Cited
1999
The FKHR gene was first identified from its disruption by the t(2;13) chromosomal translocation seen in the pediatric tumor… (More)
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Highly Cited
1999
Highly Cited
1999
Insulin inhibits the expression of multiple genes in the liver containing an insulin response sequence (IRS) (CAAAA(C/T)AA), and… (More)
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Highly Cited
1999
Highly Cited
1999
In the nematode Caenorhabditis elegans, mutations of the insulin/insulin-like growth factor-1 receptor homologue Daf-2 gene cause… (More)
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